ER低表达乳腺癌,作为一种特定表达形式,其生物学特征与ER阴性相似[1]。 ER阳性乳腺癌除从5～10年内分泌治疗获益外[2],针对人类表皮生长因子受体-2(human epidermal growth factor receptor-2,HER-2)、周期蛋白依赖性激酶4/6(cyclin-dependent kinases 4 and 6,CDK4/6)的靶向药物、针对PIK3CA基因突变的选择性磷...
ER低表达乳腺癌,作为一种特定表达形式,其生物学特征与ER阴性相似[1]。 ER阳性乳腺癌除从5～10年内分泌治疗获益外[2],针对人类表皮生长因子受体-2(human epidermal growth factor receptor-2,HER-2)、周期蛋白依赖性激酶4/6(cyclin-dependent kinases 4 and 6,CDK4/6)的靶向药物、针对PIK3CA基因突变的选择性磷...
2. Howell, S.J., Johnston, S.R., and Howell, A. (2004). The use of selective estro- gen receptor modulators and selective estrogen receptor down-regulators in breast cancer.Best Pract. Res. Clin. Endocrinol. Metab. 18, 47–66.3. Shiau, A.K., Barstad, D., Loria, P.M., Cheng...
参考文献: [1]Kimberly H. Allison et al., Estrogen and Progesterone Receptor Testing in Breast Cancer: ASCO/CAP Guideline Update. JCO 38, 1346-1366(2020). [2]Early Breast Cancer Trialists' Collaborative Group (EBCTCG),. Relevance of breast cancer hormone receptors and other factors to the ef...
Xia Song, Lin Qiong, Estrogen Receptor Bio-Activities Determine Clinical Endocrine Treatment Options in Estrogen Receptor-Positive Breast Cancer.[J] .Technol Cancer Res Treat, 2022, 21: 15330338221090351. 材料由阿斯利康支持,仅供医疗卫生专业人士参考 ...
2. Bidard FC, Kaklamani VG, Neven P, et al. Elacestrant (oral selective estrogen receptor degrader) versus standard endocrine therapy for estrogen receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer: ...
(HER2)-low, estrogen-receptor (ER) expression immunohistochemistry (IHC) 0-10% metastatic breast cancer (mBC). ESMO BC, 192MO [8]Modi S, Jacot W, Yamashita T, et al. Trastuzumab Deruxtecan in Previously Treated HER2-Low Advanced Breast Cancer. N Engl J Med. 2022;387(1):9-20. doi...
雌激素受体(estrogen receptor,ER)作为乳腺癌的生物学标志物,影响着乳腺癌内分泌治疗的选择。美国临床肿瘤学会和美国病理学家学会(American Society of Clinical Oncology /College of American Pathologists,ASCO/CAP)指南(2010年)将ER≥1%定为ER阳性,ER<1%定为ER阴性。ASCO/CAP指南(2020年)中,新增ER在1%～10%定...
1、Benefield, Halei C et al. “Borderline Estrogen Receptor-Positive Breast Cancers in Black and White Women.” Journal of the National Cancer Institute vol. 112,7 (2020): 728-736. doi:10.1093/jnci/djz206 2、Gr...
据最新发表于CA Cancer J Clin杂志的全球癌症数据统计,全球每年乳腺癌新发病例约210万,死亡病例62.7万,在所有导致死亡的癌症类型中排名第二【1】。乳腺癌细胞可以依据其表达雌激素受体(Estrogen receptor, ER)、孕激素受体 (Progesterone receptor, PR) 的情况以及表皮生长因子受体2(Epidermal growth factor receptor ...