结论子宫内膜癌组织中ER、PR的表达状态与癌细胞增殖、凋亡、迁移和转移的恶性生物学行为特征密切相关,对指导临床的治疗具有重要意义。 关键词: ER;PR;子宫内膜癌;增殖;凋亡 ABSTRACT ObjectiveTo investigate the proliferation and apoptosis activity of cancer cells in ER and PR positive endometrial carcinoma. Meth...
Konstantinopoulos PA, Lee EK, Xiong N, et al. A phase II, two-stage study of letrozole and abemaciclib in estrogen receptor-positive recurrent endometrial cancer. J Clin Oncol. Published online September 29, 2022. doi:10.1200/JCO.22.00628 END (来源:《肿瘤瞭望》编辑部) 声明 凡署名原创的文章...
参考文献 Konstantinopoulos PA, Lee EK, Xiong N, et al. A phase II, two-stage study of letrozole and abemaciclib in estrogen receptor-positive recurrent endometrial cancer. J Clin Oncol. Published online September 29, 2022. doi:10.1200/JCO.22.00628...
Endometrial cancerSurvivalHormone receptor statusERPRTo measure association between endometrial carcinoma ER and PR status and endometrial cancer (EC) survival, accounting for inter-observer variation.The intensity and proportion of tumor cell expression of ER and PR in ECs were assessed independently and...
To better discern the prognostic significance of estrogen-progesterone (ER-PR) receptor proliferative index, tumor suppressor gene, and over expression of oncogene c-erbB-2 in correlation with survival time and recurrence of tumor.Paraffin blocks from 65 cases of endometrial carcinoma diagnosed and tre...
usinghormonaltherapy.ThepresenceofER,PR,BCL2,Ki67were detectedbyimmunohistochemicalstaining.ResultsInboththe glandularepitheliumandstromaofendometrialpolyps,ER,BCL2 andKi67showedsignificantlymorepositivestainingthanthe inactiveendometriumfromthecontrolgroup(P<0.05).Therewas ...
PR,BCL2,Ki67 were detected by immunohistochemical staining.Results In both the glandular epithelium and stroma of endometrial polyps,ER,BCL2 and Ki67 showed significantly more positive staining than the inactive endometrium from the control group(P<0.05).There was no difference in expression of ...
Roundtable Roundup: ER+/PR+, HER2– Breast Cancer Bispecific T-Cell Engagers Raise Questions on Target Selection and Drug Administration Barroilhet Reviews New Endometrial Cancer Data of Later-Line Therapy Closing the Communication Gap Is Key to Integrating Whole-Person Care Into Oncology Combination...
Poly(ADP-ribose) polymerase 1 (PARP1) is essential for the progression of several types of cancers. However, whether and how PARP1 is stabilized to promote genomic stability in triple-negative breast cancer (TNBC) remains unknown. Here, we demonstrated t
子宫内膜癌(endometrialcancer,EC)是女性生殖道常见 的肿瘤之一,约占女性癌症总数的7%,占女性生殖道恶性肿 瘤的20%一30%,且近年发病率无论是西方国家还是我国均 有升高趋势,在我国,其发病率可能仅次于宫颈癌。子宫内 膜癌的确切病因仍不清楚,但现已普遍公认,雌激素长期刺 ...