[3]Chen H, Gui X, Zhou Z, et al. Distinct ER and PR expression patterns significantly affect the clinical outcomes of early HER2-positive breast cancer: A real-world analysis of 871 patients treated with neoadjuvant therapy. Breast. 2024 Jun;75:103733.[4]Allison KH, Hammond MEH, Dowsett...
免疫组织化学是目前ER、PR检测的最佳方法。该方法具有很好的特异性和敏感性,且简单、易行,也是目前ER、PR检测中使用最普遍的方法。但由于组织处理、染色方法、判读标准等影响,ER、PR的免疫组织化学检测中还存在诸多问题。因此在已获实践验证和达成共识的...
(2011) Measurement of ER and PR status in breast cancer using the QuantiGene2.0 assay. Pathology 43 , 248-253 /Chae BJ, Bae JS, Yim HW, Lee A, Song BJ, Jeon HM, et al. Measurement of ER and PR status in breast cancer using the QuantiGene2.0 assay. Pathology 2011; 43: 248-253...
因此,PR 对乳腺癌分型及预后有重要意义。PR水平与OS、TTF、内分泌治疗反应和复发时间呈正相关。 主要用药一览表 参考文献: [1]Kornelia Polyak. On the birth of breast cancer. Biochimica et Biophysica Acta,2001,1552:1-13 [2]Lila E, Nachtigall, M...
AR-positive breast cancer, significant gaps remain in understanding AR’s precise functions and therapeutic potential. The systemic management of breast cancer is guided primarily by theranostic biomarkers; ER, PR, HER2, and Ki67 which also dictate the breast cancer classification. The ubiquitous ...
【1】Sun, X., Tang, H., Chen, Y. et al. Loss of the receptors ER, PR and HER2 promotes USP15-dependent stabilization of PARP1 in triple-negative breast cancer. Nat Cancer (2023). https://doi.org/10.1038/s43018-023-00535-w
虽然目前仍无法确定原发病灶与脑转移病灶Ki-67指数的变化是否与患者的生存期有关,但这为今后的研究提供了方向。 参考文献 Chen JX; Zhou JM; Zhang HQ, et al. Conversion of ER, PR, HER2 and Ki-67 and Prognosis in breast cancer metastases to the brain. 10.21203/rs.3.rs-1692389/v1....
Ruta D. Rao, MD, and Virginia G. Kaklamani, MD, discuss with participants the case of a patient with breast cancer who has received multiple lines of therapy and what the next steps are for her treatment. CASE SUMMARY Initial presentation: A 56-year-old, postmenopausal woman presented ...
Risk of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative breast cancer is reduced in women who breastfeed and use of oral contraceptives (OCs) does not raise the risk of the disease. So say findings from a population-based study presented at the...
breast tissue.BRMS1 gene expression was presented as the ratio of BRMS1 mRNA to GAPDH mRNA.ER and PR were detected with immunohistochemical assay.Results The expression level of BRMS1 was significantly lower in breast cancer tissue than that of the adjacent tissue(P0.01)and normal lung tissue(...