The eQTL-seq scaled down the major seed weight QTLs/eQTLs into the potential candidate gene(s) governing cis- and trans-regulated expression to decipher the gene regulatory modules controlling complex quantitative seed weight trait by deriving global allele-specific gene expression polymorphism in chick...
将14个eQTL数据集合并到“MetaBrain”资源中,以最大的统计功效检测eQTL,并创建一个脑特异性基因共调控网络(图2)。在质量控制(QC)之前,MetaBrain包括来自AMP-AD联盟(AMP-AD MAYO、ROSMAP和MSBB)、Braineac、PsychENCODE联盟 (Bipseq4、BrainGVEX4、CMC9、CMC_HBCC和UCLA_ASD4)、BrainSeq、NABEC、TargetALS和GTEx。
eQTLsingle 是一个独特而强大的工具,可以利用大量的 scRNA-seq 资源进行单细胞 eQTL 研究。 eQTLsingle has two modes. Cleaned-data mode: take input as SNV matrix and expression matrix from single cells. If you have had SNV and expression information of the same cell before, you can use this mod...
ChIP-seq可以Identify direct and indirect protein-DNA interactions ChIP-seq preferred for functional information 原始数据: DHSs H3K4me3 H3K9ac H3K27ac H3K4me1 处理后数据: Enhancer TFBSs 主要是ChIP-seq(immunological assays)占了很大一类,把它搞懂就行。 另一类non-immunological assays:ATAC-seq, MNase-s...
SCS【32】基于scRNA-seq数据中推断单细胞的eQTLs (eQTLsingle)https://mp.weixin.qq.com/s/TDqg6kfX0E64T21MVmaioQ关注桓峰基因公众号,获得更多学习资源!桓峰基因推出全新生信分析文字版和视频版免费教程,欢迎大家来围观,在公众号搜索即可获得相关教程!有测序,生信分
Sun W, Hu Y (2013) Eqtl mapping using Rna-Seq data. Stat Biosci 5:198-219Sun W, Hu Y. eQTL Mapping Using RNA-seq Data. Stat Biosci. 2013; 5(1):198-219.Sun, W. and Hu, Y. (2013). "eQTL Mapping Using RNA-seq Data." 5, 1, 198-219....
As RNA-seq is replacing gene expression microarrays to assess genome-wide transcription abundance, gene expression Quantitative Trait Locus (eQTL) studies using RNA-seq have emerged. RNA-seq delivers two novel features that are important for eQTL studies. First, it provides information on allele-spec...
A unified framework for cell-type-specific eQTL prioritization by integrating bulk and scRNA-seq data 来自 dx.doi.org 喜欢 0 阅读量: 1 作者:X Yu,X Hu,X Wan,Z Zhang,X Wan,M Cai,T Yu,J Xiao 摘要: This paper introduces IBSEP, a statistical framework that integrates bulk and scRNA-seq...
http://eqtl.brainseq.org/ 项目旨在描述主要神经精神疾病和对照样本中不同脑区域转录的多个方面的遗传和表观遗传调控特征。该联盟最初专注于精神分裂症和情绪障碍,其目标是阐明遗传关联的潜在分子机制,以确定新的治疗靶点。 该联盟目前由7家制药公司和一家非盈利医疗研究机构组成。
常见基因组功能数据介绍 | 表观注释 | DNase-seq | ChIP-Seq | ATAC-Seq | eQTL | ENCODE | ROADMAP,functionalgenomics|epigenomicannotations刚入行的总是一头雾水,对这些表观的标记一点兴趣都没有,种类繁多,总是记不住,这里我就做一个常识性的总结,不搞太多术语。