2.2.4. Loading of EPL onto NE Formulations For EPL loading onto NE formulations, an excess amount of drug (150 mg) was added to the optimized oil/Smix mixture and constantly stirred using a mechanical stirrer until a homogenous mixture was obtained. The required amount of water was added in...
Introduction Eplerenone (2, Figure 1) is a cardiovascular drug indicated for the treatment of essential hypertension and congestive heart failure that, in contrast to its predecessor spironolactone 1 (Figure 1) demonstrates a high degree of selectivity for the aldosterone receptor and a low-binding ...