These TA cells are thought to divide subsequently, several times, amplifying the number of stem cell derived cells before sub sequent terminal differentiation into tissue specific epithelial cells, e. g. corneal epithelial cells. Recent data employing anti-keratin antibodies have demonstrated that ...
Simple epithelia are defined as epithelia which areone cell layerthick – i.e. every cell attaches to the basement membrane. The basement membrane is a thin but strong, acellular layer which lies between the epithelium and the adjacent connective tissue. It is sometimes referred to as the “ba...
This cooperation may differ depending on cell type, tissue context, and extent of the plasticity response. TGF-β family proteins are potent inducers of EMT programs The TGF-β family consists of homo- and heterodimers, and includes TGF-βs, activins, and bone morphogenetic proteins (BMPs) (...
Tissue microarray technology was used to immunohistochemically stain for supervillin antibody in 173 HCC tissue specimens and expression levels correlated with the clinicopathological variables. Tumor cell motility and invasiveness, as well as changes in the mRNA expression levels of genes associated with ...
Given the high expression of wound response genes in the tissue adjacent to cancer [58] and the important role of HGF in normal ductal morphogenesis and invasive breast cancer, a better understanding of HGF/MET in progression of basal-like breast cancers is important. Future work should focus ...
The diagram was created using BioRender. (f) Representative H&E and MT images, (g) evaluation of fibrotic disease (n = 4 per group) (*p = 0.0400), (h) representative immunofluorescence images staining AT1 (PDPN+) and AT2 (proSP-C+) cells, and (i) quantification of tissue ...
Inscuteable expression has a multiplicative effect on popping out, increasing the number of misplaced cells in tissue mutant for either Nrg14 or Fas2G0336 by ∼6-fold (Figure 1D). Because Inscuteable has the same effect for Nrg14, Fas2G0336 double mutants, we conclude that the increase ...
To explore the effect of miR-3653 on breast cancer development, we performed qPCR to detect miR-3653 levels in 100 pairs of tumor and adjacent tissue samples. The expression of miR-3653 in tumor tissues was lower than that in paracancerous tissues (0.054 ± 0.013 vs. 0.131 ± 0.028, t=...
differentiate. Thus, at the individual cell level, stem cells can divide symmetrically; however, at the population level, these divisions are asymmetric in that they are balanced such that homeostasis is maintained within the tissue. How this balance is maintained is not yet clear....
promotes severe recurrent bacterial infections6,7,8. Thus, depending on disease history, the bladder tissue is differentially remodelled in a way that either increases or decreases susceptibility to rUTI. These phenotypes led to our hypothesis that bladder mucosal remodelling is mediated in part by ...