Selective amygdalohippocampectomy (SAH) can be carried out in classic medial TLE cases, and laser interstitial thermal therapy (LITT) should be considered as a minimally invasive alternative to open SAH when it is available. Overall SAH success rate is lower in pediatric patients than in adults...
Laser Ablation Therapy, using MRI guidance, a laser uses heat to eliminate the brain tissue causing abnormal electrical activity Disconnection surgery like Corpus Callosotomy or hemispherectomy/hemispherectomy, disconnecting a seizure network, depending on the type of epilepsy Neuromodulation Therapy ...
brain damage is possible 45% say concern for loss of independence Almost 30% of patients had pre-existing negative attitudes Over half of that 30% were completely opposed 73% think surgery should be the last resort 56% would not undergo surgery unless a 100% success rate Erba G, et al. ...
Epilepsy surgery is a useful but underutilized approach to intractable pediatric epilepsy. In some cases, potentially curative operations can be performed in an attempt to either resect or disconnect the epileptogenic zone. The success of these operations may depend highly on a number of other factor...
ipsilateral to KA injection targeting the DG, and an electromyographic electrode implanted in the cervical trapezius neck muscle (Fig.1b, c). After recovering from the implant surgery, mice were continuously video-EEG monitored, and TLE onset was determined by the occurrence of the first detected...
Briefly, ketamine (100 mg/kg), xylazine (10 mg/kg), and buprenorphine SR (0.5 mg/kg) were administered subcutaneously for anesthesia and analgesia before surgery. Hair on the scalp was removed. The mice were then positioned in a stereotaxic frame at 37 °C using a homeothermic blanket ...
Open brain surgery is the standard treatment for patients with intractable MTLE. Surgery has a high success rate, but carries a significant risk of neurological and cognitive (intellectual) impairment. Minimally invasive approaches like the new MRI-guidedlaserablation technique might produce similar seiz...
While traditionally the mainstay of surgical treatment has been open brain resection, recent innovations have allowed for less invasive ablative techniques such as MRI-guided laser interstitial thermotherapy (LITT). A brief review of the different technical approaches and methods follows. 6.1. Surgery ...