Epigenetics refers to changes in gene expression/organism phenotype that occur without altering the DNA sequence. A delicate balance exists between the epigenome (the representative genome that includes all inhibitory and activating, covalent and chemical markers), and the environment that shapes ...
Epigenetics refers to changes in phenotype and gene expression that occur without alterations in DNA sequence. MicroRNAs are relatively recently discovered negative regulators of gene expression and act at the posttranscriptional level.This review summarizes epigenetic mechanisms of pulmonary hypertension, ...
Epigenetics refers to heritable changes in gene expression that arise from changes in chromosomes without alteration of DNA sequence. These changes occur throughout all stages of development or in response to environmental factors such as exposure to toxins or chronic stress and are implicated in disea...
Epigenetics often refers to changes in a chromosome that affect gene activity and expression, but can also be used to describe any heritable phenotypic change that does not derive from a modification of the genome, such as prions. Such effects on cellular and physiological phenotypic traits may re...
Theterm‘‘epigenetics’’referstoheritablechangesingeneexpression,whicharenotaresultofchangesintheDNAsequence,butratherduetoalterationsrelatedtothepackaging(therebyalteringDNAaccessibility)and/ortranslationofgeneticinformation.Startingfromthemid-1990s’,therehasbeenasteadygrowthinthenumberoflaboratoriesandinvestigators...
The term epigenetics refers to changes in phenotype (appearance) or gene expression caused by mechanisms other than changes in the underlying DNA sequence, hence the name epi- (Greek: over; above) genetics. The basic discovery is that non-genetic factors can cause an organism’s genes to behav...
Epigenetics refers to heritable changes in gene expression that do not alter the DNA sequence. These changes are driven by mechanisms such asDNA methylation,histone modifications, andnon-coding RNA interactions, which regulate gene activity. Influenced by environmental and lifestyle factors, epi...
In biology, the term epigenetics refers to changes in phenotype (appearance) or gene expression caused by mechanisms other than changes in the underlying DNA sequence, hence the name epi- (Greek: over; above) -genetics. These changes may remain through cell divisions for the remainder of the ...
This review encompasses the different types of epigenetic changes, the interplay among them and the implications of these epigenetic changes in relation to cancer and ageing. Besides this, the development and perspective of epigenetic therapy has also been discussed in brief. 展开 ...
and the increased access to the epigenetic profiles of different tissues has begun to shed light on the genetic complexity of many basic biological processes, both physiological and pathological. Epigenetics refers to heritable changes in gene expression that are not due to alterations in the DNA seq...