The mitoepigenetics refers to the epigenetic modification of genes encoded by mitochondria itself, such as mitochondrial DNA (mtDNA) methylation, the mitochondrial epigenetic regulation by the cell metabolites and the modifications of genes related with mitochondrial functions, which may reveal the ...
In HCC the patterns and frequencies of somatic variations change depending on the nearby chromatin. On the other hand, epigenetic alterations often induce genomic instability prone to mutations. Epigenetics refers to heritable states of gene expression without alteration to the DNA sequence itself and, ...
The term epigenetics refers to mechanisms that alter gene activity without changing the genetic sequence22. The three fundamental classes of epigenetic mechanisms are DNA modifications, histone modifications and non-coding RNA. The most prevalent and widely researched DNA modification is DNA methylation, ...
Oncogenic pathways that drive cancer progression reflect both genetic changes and epigenetic regulation. Here we stratified primary tumors from each of 24 TCGA adult cancer types based on the gene expression patterns of epigenetic factors (epifactors). T
(Wang et al.2017). The following study showed that this may be caused by HDA6-mediated suppression of SA biosynthesis. HDA6 can directly bind to the promoter regions to repress the expression ofCALMODULIN-BINDING PROTEIN 60 g(CBP60g) andSYSTEMIC-ACQUIRED RESISTANCE-DEFICIENT 1(SARD1) through ...
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Cancer, the leading cause of global human death, refers to the proliferation of local histiocytes caused by some tumorigenic factors. The whole process is generally divided into four stages: precancerous lesion, carcinoma in situ, invasive carcinoma and metastasis [1,2]. Cancer represents a compl...
Cardiovascular disease (CVD) refers to a group of disorders that affect the heart or blood vessels, of which the most common types are coronary heart disease and stroke [1]. CVD is a global public health concern, many risk factors have been associated with CVD, and new factors emerge with...
Steroid hormone signaling was first correlated to breast cancer progression in 1896 when surgical removal of both ovaries of breast cancer patients resulted in tumor regression, providing rationale for endocrine therapy47. Endocrine therapy, the standard of care for ER+ breast cancer, refers to those...
This approach proposes targeting of epigenetic regulators, which are proteins involved in the creation, detection and interpretation of epigenetic signals. The term epigenetics refers to all of the chemical changes that can modulate gene expression and can be transmitted through mitosis and meiosis ...