N2a cells transfected with pCMV6-Tau plasmid were treated with PU-AD for 24 h followed by 24 h drug wash off. Equal amounts of control and treated cell lysates (0.5 µg) were added to each well followed by PU-FITC (10 nM) in a final volume of 100 μl assay buffer...
Sidney J. Furie directs this 1972 film that tells the story of the life of Billie Holliday, portrayed by Diana Ross. It centers around her struggles and heavy drug use, throughout the majority of her young life. Nicknamed Lady D, Holiday had a ma...
https://ror.org/02yrq0923grid.51462.340000 0001 2171 9952Radiochemistry & Molecular Imaging Probes CoreMemorial Sloan Kettering Cancer Center New York NY USASusana Ravassagrid.413448.e0000 0000 9314 1427Program of Cardiovascular DiseasesCenter for Applied Medical Research Universidad de Navarra, Navarra...
New York, NY: Oxford University Press; 2006. doi:10.1093/acprof:oso/9780195179484.001.0001 3. Wright DW, Yeatts SD, Silbergleit R, et al; NETT Investigators. Very early administration of progesterone for acute traumatic brain injury. N Engl J Med. 2014;371(26):2457-2466. doi:10.1056/...
Sonny, acting as Don of the family, savagely beats his sister's husband, Carlo, who has been abusing here. In retaliation, Carlo arranges Sonny's brutal murder. Don Vito, after Sonny's death, capitulates and agrees to join the five families in the drug market. ...
In Protein Homeostasis in Drug Discovery: A Chemical Biology Perspective; Wiley: New York, NY, USA, 2022; pp. 1–26. [Google Scholar] Oliveira, B.L.; Guo, Z.; Bernardes, G.J.L. Inverse electron demand Diels–Alder reactions in chemical biology. Chem. Soc. Rev. 2017, 46, 4895–...
Keywords: infections;intensive care unit;antimicrobial stewardship;infection control;drug resistance;bacterial;point prevalence study
zelavespib; epichaperomes; drug–target residence time; target–ligand interactions; target engagement and occupancy; mechanisms of drug action; icapamespib; drug discovery for cancers and neurodegenerative diseases1. Introduction As in all fields of drug therapy, knowing the right molecular target ...