前言 研究表明,Epcam(epithelial cell adhesion molecule,上皮细胞黏附分子)参与了肿瘤干细胞、细胞增殖、代谢、血管生成、上皮向间充质转化(EMT)、转移、化疗/放射抵抗和免疫调节等过程。在肿瘤发展过程中,EPCAM会与许多关键信号通路如Wnt/β-catenin、转化生长因子-β/SMAD、Epex/EGFR、PI3K/Akt/mTor和P53等发生串...
前言 研究表明,Epcam(epithelial cell adhesion molecule,上皮细胞黏附分子)参与了肿瘤干细胞、细胞增殖、代谢、血管生成、上皮向间充质转化(EMT)、转移、化疗/放射抵抗和免疫调节等过程。在肿瘤发展过程中,EPCAM会与许多关键信号通路如Wnt/β-catenin、转化生长因子-β/SMAD、Epex/EGFR、PI3K/Akt/mTor和P53等发生串...
Kuan I, Liang K, Wang Y, Kuo T, Meir Y, Wu S, Yang S, Lu J and Wu H 2017 EpEX/EpCAM and Oct4 or Klf4 alone are sufficient to generate induced pluripotent stem cells through STAT3 and HIF2α. Scientific Reports. 7 41852
EpEXand Sox2were confirmed as prognosticators of clinical outcome in the validation cohort treated with definitive radio(chemo)therapy. Importantly, EpEXidentified patients with improved survival within the HPV-negative subgroup of the validation cohort. Hence, Sox2and particularly EpEXhave potential as ...
上皮细胞黏附分子(EpCAM)由314个氨基酸组成,包含三个结构域:胞外段结构域(EpEX),单次跨膜结构域和胞内结构域(EpICD)。在一些正常组织和细胞中,如食道鳞状上皮,EpCAM蛋白表达水平较低,而在某些具有增殖能力的细胞中,如肝再生细胞,EpCAM的表达水平相对较高,在正常的胃粘膜中无EpCAM表达,但是在77%的胃癌患者胃...
具体而言,该EpCAM抑制剂为针对EpCAM的胞外结构域extracellulardomain,EpEX的抗体。结合治疗可有效诱导癌细胞凋亡、抑制癌细胞迁移侵袭、减小肿瘤大小,及或延长癌症患者的寿命。 专利权项:1.一种治疗癌症的方法,包括向有需要的个体施用i有效量的第一抑制剂,其抑制上皮细胞黏附分子epithelialcelladhesionmolecule,EpCAM...
The EpCAM protein contains an extracellular domain (EpEX) with a nidogen-like domain as well as thyroglobulin- and epidermal growth factor-like repeats, a single transmembrane region, and a short intracellular domain (EpICD) consisting of 26 amino acids. EpCAM has been shown to be expressed ...
(EpEX, 27 kDa)11,12. These units are believed to be anchored to the actin cytoskeleton via interaction of the intracellular tail (EpIC, 3 kDa) with α-actinin13. However, it was also demonstrated that EpCAM can have a negative effect on the strength of cell–cell adhesion mediated ...
Decreased immunodetection of EpEX in locally advanced GC was not associated with decreased EpCAM mRNA levels. Conclusion: All members of the EpCAM signalling pathway are expressed in GC. The expression correlated significantly with each other and with various clinico-pathological patient characteristics,...