We hypothesize that the increase in Epac1 expression is due to increased transcriptional activity of the Epac1 gene. To test this hypothesis, we cloned the 2kb promoter region directly upstream of the start site for Epac1 into the pGL4.10 luciferase reporter vector. Deletional analysis revealed ...
EPAC1 enhances differentiation of brown adipocytes To investigate the role of EPAC1 in brown adipocyte differentiation, we used the selective and preferential activator of EPAC1 8-pCPT-2′-O-Me-cAMP (hereafter, 007)16. Treatment of preadipocytes isolated from BAT with 007 resulted in an increase...
We isolated a 1614-bp DNA fragment upstream of the initiation codon of Epac1 gene, inclusive of glucose response elements (GREs). HK-2 or COS7 cells transfected with the Epac1 promoter revealed a dose-dependent increase in its activity under HGA. Mutations in GRE motifs resulted in ...
We isolated a 1614-bp DNA fragment upstream of the initiation codon of Epac1 gene, inclusive of glucose response elements (GREs). HK-2 or COS7 cells transfected with the Epac1 promoter revealed a dose-dependent increase in its activity under HGA. Mutations in GRE motifs resulted in ...
We hypothesize that the increase in Epac1 expression is due to increased transcriptional activity of the Epac1 gene. Deletional analysis of the 2kb promoter region directly upstream of the start site for Epac1 revealed that the region necessary for basal expression of Epac1 is located within ...
背景资料Rap guanine nucleotide exchange factor 3 also known as exchange factor directly activated by cAMP 1 (EPAC1) or cAMP-regulated guanine nucleotide exchange factor I (cAMP-GEFI) is a protein that in humans is encoded by the RAPGEF3 gene.As the name suggests,EPAC proteins (EPAC1 and EP...
Epac proteins are cAMP sensors that regulate several pivotal cellular processes, including calcium handling, cell proliferation, cell survival, cell differentiation, cell polarization, cell adhesion events, gene transcription, secretion, ion transport, and neuronal signaling. It is a potential target for ...
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Activation of Protein Kinase Cα by EPAC1 Is Required for the ERK- and CCAAT/Enhancer-binding Protein β-dependent Induction of the SOCS-3 Gene by Cyclic A... We recently found that induction of the anti-inflammatory SOCS-3 gene by cyclic AMP occurs through novel cyclic AMP-dependent ...