IL1RAP/IL-1RAcP 基因概述 IL1RAP gene / cDNA is a protein-coding gene which located on 3q28. The IL1RAP gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, and frog.218 organisms have orthologs with human gene IL1RAP. ...
Mice deficient for the IL-1RAcP gene (IL-1RAcP KO) were used to explore the role of IL-1RAcP in physiological functions of brain IL-1β. Animals were injected i.c.v. with two different doses of recombinant human (rh) IL-1β: a small one (750 pg) known to induce sickness ...
IL-1RAcP is an indispensible molecule in the IL-1 receptor signal transduction complex, links events at the plasma membrane level to downstream signaling pathways, mediates interleukin-1-dependent transcription factor activation and gene expression.IL-1RAcP plays an essential role in the inflammatory ...
These results proved that IL-1RAcP is an indispensible molecule in the IL-1 receptor signal transduction complex, necessary to link events on the plasma membrane level to downstream signaling pathways, allowing IL-1-dependent activation of transcription factors and...
A homodimeric protein combining human IL-1R1 with human IL-1RAcP polypeptide fragments and the use. A human IL-1R1 gene has a mutation at a single nucleotide site on the basis of a wild type, i.e., a nucleotide of a coding K131 site is mutated from AAA to GAA, so that a K131...