近日,国际期刊医学基因组学杂志《BMC Medical Genomics》杂志(影响因子3.622,中科院3区)发表题为“Case report: a Chinese girl like atypical Rubinstein–Taybi syndrome caused by a novel heterozygous mutation of the EP300 gene”的文章,郑州大学第一附属医院...
通过与磷酸化CREB蛋白特异性结合来介导cAMP基因调控。该基因也被鉴定为HIF1A(缺氧诱导因子1α)的共激活物,因此在缺氧诱导基因如VEGF的刺激中起到作用。这种基因的缺陷是鲁宾斯坦-泰比综合征的原因,也可能在上皮癌中起作用。 This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator ...
[5]Martin TD, Patel RS, Cook DR, et al. The adaptive immune system is a major driver of selection for tumor suppressor gene inactivation. Science. 2021;373(6561):1327-1335. doi:10.1126/science.abg5784 [6]Augert A, Zhang Q, Ba...
Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. 基因名: EP300 别名: KAT3B,RSTS2,p300 基因ID: 2033 Chromosome:(GRCh37) 22 Start: 41487790 End: 41576081 Strand: 1 信号通路: DNA修饰及其它 组蛋白修饰 细胞周期 炎症相关 肿瘤干...
基因简称(symbol) EP300 [HGNC] [GeneCards] [NCBI] 基因种类(locus group) protein-coding gene 同源简称(alias symbol) p300|KAT3B 基因家族代码(gene_family_id) 486 [HGNC] [GenScript] omim代码 602700 entrez码 2033 [Vega] ensembl基因码 ENSG00000100393 [Ensembl] 基因家族(gene family) ...
Another study provided the first evidence that theEP300gene, which encodes a HAT, behaves as a classical tumour-suppresser gene, and showed that the gene is mutated in epithelial cancers[6]. A clear association between AIB1 protein, a homologue of the acetylase SRC-1, and breast cancer has...
Phenomenon explanation:The possible reasons that the actual band size differs from the predicted are as follows:1.Splice variants: Alternative splicing may create different sized proteins from the same gene.2. Relative charge: The composition of amino acids may affects the charge of the protein.3....
To probe into copy number variation, functional divergence and correlation with hypoxia response of ep300/crebbp gene family in rainbow trout Oncorhynchus mykiss, TBLASTN and BLASTP search and reconstruction of phylogenetic tree were firstly conducted, based on which the members and the...
编写python脚本提取比对结果,过滤掉覆盖度低于30%的Hits,同时从gene2 accession文件中(下载自https://ftp.ncbi.nlm.nih.gov/gene/DATA/)提取出BLASTP搜索结果中Hits所对应的基因在染色体上的位置信息。 1.2.2 系统发育分析 基于对BLASTP搜索结果的筛选,下载相应的虹鳟蛋白质序列,与斑马鱼、小鼠和原鸡的Ep300/...
This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer....