The development, survival, and function of eosinophils are also controlled by diverse inhibitory cytokines, their receptors, and other inhibitory receptors and “negative-regulators” [49,50,51,52,53,54,55]. Among cytokines, transforming growth factor-beta (TGF-beta), interferon-alpha (IFN-alpha)...
When Paul Ehrlich first described the eosinophil in 1879, having detected blood white cells that bound eosin-like dyes with great affinity, he was unaware of the magnitude of subsequent interest in this cell, from both a clinical and biological point of view. Since his description, and particula...
Recent studies have profoundly altered this simplistic view of eosinophils and their function. New insights into the molecular pathways that control the development, trafficking and degranulation of eosinophils have improved our understanding of the immunomodulatory functions of these cells and their roles ...
After the description that Fee RII/CD23 identified on eosinophils could participate in IgE binding and IgE-mediated cytotoxicity, Mac2/ binding proteins belonging to the S-type lectin family were also detected on human eosinophits. Anti-Mac2 monoclonal antibodies inhibited eosinophil-dependent ...
When Paul Ehrlich first described the eosinophil in 1879, having detected blood white cells that bound eosin-like dyes with great affinity, he was unaware of the magnitude of subsequent interest in this cell, from both a clinical and biological point of view. Since his description, and particula...
The roles of eosinophils in homeostasis and maintenance of an efficient natural immune response have gained more attention after the description of the regulatory population of eosinophils [21]. Treatment with benralizumab, and, to a lesser extent with anti-IL-5 monoclonal antibodies mepolizumab and...
Study of the interaction between schistosomes and eosinophils was the first step leading to the description of in vitro eosinophil-mediated cytotoxicity against parasitic targets and to the role of this polymorphonuclear leucocyte in immunity to helminths. Elegant studies have been initiated by Butterworth...
Study of the interaction between schistosomes and eosinophils was the first step leading to the description of in vitro eosinophil-mediated cytotoxicity against parasitic targets and to the role of this polymorphonuclear leucocyte in immunity to helminths. Elegant studies have been initiated by Butterworth...
The cell sorting studies reported here and the demonstration of the lack of an effect of the cell preparation method on eosinophil and neutrophil expression of L-selectin add to the previous description of the use of CD16 to distinguish eosinophils and neutrophils in mixed suspensions of neonatal ...
Specific (or adaptive) immunity describes the clonal selection of B cells and T cells by a specific antigen. Adaptive immunity takes time to function (it takes approximately seven days to get up and running), however it has the...