Greater recognition and understanding of the unique immunopathology of this asthma phenotype has important implications for management of the disease and the potential to improve patient outcomes. The present review provides a summary of the clinical features, pathogenesis, diagnosis, and management of...
Whatisan“eosinophilicphenotype”ofasthmaEditorial What is an‘‘eosinophilic phenotype’’of asthma? Parameswaran Nair,MD,PhD,FRCP,FRCPC Hamilton,Ontario,Canada Key words:Sputum eosinophils,blood eosinophils,fraction of ex-haled nitric oxide,asthma,phenotype The role of eosinophils as a key player in ...
Tiotropium bromide is effective for severe asthma with noneosinophilic phenotype To the Editor: Although currently available asthma medications are very effective in the majority of cases, there remains a subgroup for which disease cont... H Iwamoto,A Yokoyama,N Shiota,... - 《European Respiratory...
The neutrophilic inflammatory phenotype is associated with systemic inflammation in asthma. Chest. 2012. https://doi.org/10.1378/chest.11-1838. CAS PubMed Google Scholar Raundhal M, Morse C, Khare A, et al. High IFN-γ and low SLPI mark severe asthma in mice and humans. J Clin Invest...
Identify the key clinical features of eosinophilic granulomatosis with polyangiitis, including asthma, rhinosinusitis, and peripheral eosinophilia, to ensure early diagnosis. Implement tailored treatment strategies for eosinophilic granulomatosis with polyangiitis, considering both the eosinophilic phenotype and antin...
There is some evidence that asthma in EGPA resembles a nonallergic eosinophilic asthma phenotype. Encouraging results have been reported for the treatment of EGPA with rituximab or with the eosinophil-targeted antiinterleukin-5 agent mepolizumab.The understanding of EGPA continues to advance, but many ...
and the expression of theeosinophilchemokineeotaxin 3. Current first line treatments such as strict dietary modification andcorticosteroidsfail many patients. Looking forward, clarification of distinct genotype/phenotype associations, determining the reversibility of remodelling following treatment, and the ...
It is today imperative to select the biologic that could provide the best possible response by targeting the recognized biological pathway underlying the specific patient phenotype10. If, for example, OMA might be more effective in subjects with polyallergy, MEP, RES and BEN could be more ...
Patients with a previous asthma diagnosis were excluded. None of the patients had infections of the upper respiratory tract or exacerbations in the previous 2 months. A written informed consent was signed by each enrolled patient. This study conformed to the declaration of Helsinki and was approved...
An allergic phenotype and the use of steroid inhalers predict eosinophilic oesophagitis in patients with asthma Summary BackgroundPatients with eosinophilic oesophagitis (EoE) commonly have asthma and atopy. AimsTo determine the predictive factors of EoE in patients ... KN Harer,FT Enders,KG Lim,....