Environmental Impacts on Enzymes Involved in Drug and Steroid Metabolism.The article introduces a series of articles on the effects of environmental chemicals on enzymes involved in drug and steroid metabolism.WaringSchool of BiosciencesR. H.School of BiosciencesCurrent Drug Metabolism...
MOLECULAR INTERACTIONS BETWEEN MYCOTOXINS AND LIVER ENZYMES INVOLVED IN DRUG METABOLISM IN RODENTS AND FARM ANIMALS 来自 ResearchGate 喜欢 0 阅读量: 34 作者:P Galtier,GM Meissonnier,J Laffitte,IP Oswald,N Loiseau 摘要: Mycotoxins are well known for underging liver biotransformation in humans and ...
Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacol Ther 2013;138:103-... UM Zanger,M ...
drug metabolizing enzymes CYP3A4 CYP1A2 glutathione S-transferases HepG2 cells Salvianolic acid BBACKGROUND: Enzymes involved in drug and xenobiotic metabolism have been considered to exist in two groups: phase I and phase II enzymes. Cytochrome P450 isoenzymes (CYPs) are the most important phas...
Functional importance of the enzymes (IPCS, SPT and SPL) in the sphingolipid metabolism of Leishmania . Full size image The sphingolipid metabolism of Leishmania and many other pathogens is highly conserved and offers a series of attractive drug targets for further inhibitor design. IPCS, SPT and ...
摘要: that the aromatic ring is not an essential component for potent MAO-B inhibition; 46 is For example,whereas MAO-B inhibitors (eg L-deprenyl) are used successfully in Parkinson's patients to Forexample, L-deprenyl and MDL 72974A effectively inhibit the development of a drug...
The basic principles of drug metabolism and its enzyme are discussed, with an emphases on the interindividual variations and ethnic differences of two monooxygenases (cytochrome P450 CYP2D6 and CYP2C19) and one conjugation enzyme ( N acetyltransferases). Some applications of phenotyping genotyping of ...
To further examine the roles of gut bacteria in the colonic metabolism of TCS, we tested the time-dependence of the antibiotic effects. Mice were pre-treated with or without the antibiotic cocktail, then received TCS via a one-time oral gavage, after which the metabolic profile of TCS was ...
It is believed to be underlie by inherited genetic predispositions related to the genetic polymorphism of several enzymes involved in the detoxification and xenobiotic metabolism. In this review, we collect and discuss the evidence reported up to date on the association between lung cancer and genetic...
Crystal structure and pH-dependent allosteric regulation of human β-ureidopropionase, an enzyme involved in anticancer drug metabolism β-Ureidopropionase (βUP) catalyzes the third step of the reductive pyrimidine catabolic pathway responsible for breakdown of uracil-, thymine- and pyrimi... M Dir...