DRUG-DRUG INTERACTIONS VIA INHIBITION OF MICROSOMAL ENZYMES INVOLVED IN METABOLISM OF EPOXIDES PRODUCED BY MICROSOMAL MONOOXYGENASE - ScienceDirectF. OeschH.R. GlattP. BentleyELSEVIERMicrosomes and Drug Oxidations
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Other Enzymes Involved in Tamoxifen Metabolism Consequences for Molecular Diagnostics Aromatase Inhibitors CYP19A1 Genetics AI Metabolism & the Role of Polymorphisms in DMEs Letrozole Anastrozole Exemestane Conclusion of DME Impact on Clinical Outcome of AI Therapy Expert Commentary Five-Year View References...
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The impact of this downregulation on P450‐mediated drug metabolism was also studied. In addition, the expression of several nuclear receptors that are potentially involved in the regulation of intestinal P450 expression was compared between control and DSS‐treated groups. Whereas no difference was ...
To further examine the roles of gut bacteria in the colonic metabolism of TCS, we tested the time-dependence of the antibiotic effects. Mice were pre-treated with or without the antibiotic cocktail, then received TCS via a one-time oral gavage, after which the metabolic profile of TCS was ...
Cytochrome P450 (CYP) is mainly involved in the primary metabolism of the cannabinoids in hepatic microsomes (Yamamoto et al., 1995). Our previous studies demonstrated that the major CYP enzymes involved in the hepatic metabolism of THCs in mice and male rats are CYP2C29 (Watanabe et al.,...
A study using DNA microarray showed a broad downregulation of genes involved in drug metabolism in the colon biopsy specimens obtained from both UC and CD patients. The expression of MDR1, but not of MRP2/3, is significantly decreased in colon samples of UC patients. This dysregulation is ...
Novel metabolites and enzymes involved in skatole metabolism are disclosed. The novel metabolites are 3-OH-3-methylindolenine (HMI); 3-methyloxindole (3MOI); indole-3-carbinol (I-3C); and 2-aminoacetophenone (2-AM). Measuring levels of these metabolites in a pig may be useful in identify...