Bosentan could induce the metabolism of amiodarone while amiodarone may inhibit bosentan metabolism. A study of the concurrent administration of inhibitor ritonavir and inducer St. John's wort revealed a predominant effect of enzyme inhibition.EBSCO_AspPharmacy Times...
Recently a study was done to examine the effects of ritonavir (a CYP3A4 inhibitor) and St. John’s wort (a CYP3A4 inducer) alone and in combination on the metabolism of midazolam.1 Twelve subjects received single oral doses of midazolam alone and with single doses of St. John’s wort...
___ inhibitor→inhibidor enzimático; ___ therapy→terapia de ___ -s. English-Spanish Medical Dictionary © Farlex 2012 enzyme nenzimam&f; [Note: Masculine usage predominates in Spain, while feminine usage predominates in Latin America.] ...
Enzyme induction involves the synthesis of protein which leads to increased levels and activity of the enzyme. This process usually takes about 2 weeks after the start of the enzyme inducer, although de-induction after stopping the inducer is a quicker process (typically less than 5 days). The...
Theoretical plasma concentration–time profiles of a drug in the presence of a CYP enzyme inducer (dashed line) and inhibitor (solid line). In reversible inhibition, enzymatic activity is regained by the systemic elimination of inhibitor, such that the time to enzyme recovery is dependent on the...
Examples of enzyme inducers includeaminoglutethimide, barbiturates, carbamazepine, glutethimide, griseofulvin, phenytoin, primidone, rifabutin, rifampin, and troglitazone. Some drugs, such as ritonavir, may act as either an enzyme inhibitor or an enzyme inducer, depending on the situation. ...
induced enzyme(inducible enzyme) one whose production requires or is stimulated by a specific small molecule, the inducer, which is the substrate of the enzyme or a compound structurally related to it. proteolytic enzymeone that catalyzes the hydrolysis of proteins and various split products of prot...
In Hepa-1 wt cells, NMO1 and AHD4 activities were increased by the aromatic hydrocarbon inducer 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and by the electrophile tert-butylhydroquinone (tBHQ), known inducing agents for these enzymes. However, NMO1 and AHD4 were induced in Ah receptor ...
RNA polymerase activity in a midgut nuclear fraction from southern armyworm larvae exposed to the microsomal enzyme inducer pentamethylbenzene (PMB, 2000 p... NA Elshourbagy,CF Wilkinson - 《Insect Biochemistry》 被引量: 5发表: 1978年 Photolysis products of 2,4,5,2′,4′,5′-hexabromobiphe...
The possible influence of enzyme induction on the changes in the pharmacokinetic of rifampicin have been investigated in comparison with the effect of a known enzyme inducer (phenobarbitone) on the kinetic of rifampicin itself. A similar trend to a decrease of rifampicin half-life time has been ...