Furthermore, we pioneered techniques that can be used to evaluate a candidate gene for the ability to confer resistance when over-expressed in genetically engineered cells.University of South Carolina.Nivens, Michael Chadham.University of South Carolina....
"Enzymes that do a prodigious job of catalysis are, hands-down, the most sensitive targets for drug development," Wolfenden said. "The enzymes we study are fascinating because they exceed all other known enzymes in their power as catalysts." Wolfenden has carried out extensive research on enzyme...
5a, b), and key residues involved in catalysis were examined. Both HPAD and IAD contain the G• and cysteine thiyl radical (Cys•) residues conserved in all GREs. In addition, the mechanism of HPAD is thought to involve a Glu that coordinates the Cys• (Glu1), and a Glu that ...
distributions flanking the TMD23,24. Previous results from our lab support the 3-TM topology model of VKOR and demonstrate that the loop cysteines are unnecessary for active site regeneration20,21. Furthermore, computational simulations suggest that the 3-TM model of human VKOR is more stable ...
The sirtuins are NAD+-dependent, multifunctional lysine deacylases that play key roles in cellular homeostasis. They are increasingly being found to target a variety of substrates including acetyl-, butyryl-, malonyl-, and succinyl-lysines. Early assays for measuring sirtuin activity in vitro were...
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