Enzyme active-site predictionTitration CurveAldose ReductaseEnzyme Active SiteTriosephosphate IsomeraseWinged BeanA new method for identifying the active site of an enzyme from structural information alonedoi:10.1186/gb-2001-3-1-reports0003Agnieszka M LichanskaBioMed CentralGenome Biology...
Calculations of charge interactions complement analysis of a characterised active site, rationalising pH-dependence of activity and transition state stabilisation. Prediction of active site location through large Δp K as or electrostatic strain is relevant for structural genomics. We report a study of ...
5.33.6.1Enzyme Active Site/Substrate Models Any systems that can be used to predict specific aspects of metabolism could be used to contribute to a global prediction program. The most obvious is a system to predict the affinity of substrates forcytochrome P450 isozymesand the distribution of produc...
Easily build 3D enzyme structures directly from sequence and understand substrate binding to the active site Import, analyze, and edit protein sequences, including quick sequence alignment and annotation with Multiple Sequence Viewer Create high-quality homology models from sequence using a fully automated...
1 Prediction of Enzyme Catalytic Sites from Sequence Using Neural Networks Swati Pande California State Polytechnic University, Pomona..
A library of 181 active site motifs has been created with ProMOL, based on definitions published in the Catalytic Site Atlas (CSA). Searches with ProMOL produce better than 50% useful Enzyme Commission (EC) class suggestions for level 1 searches in EC classes 1, 4 and 5, and produce some...
Enzyme active sites are important and conserved functional regions of proteins whose identification can be an invaluable step toward protein function prediction. Most of the existing methods for this task are based on active site similarity and present limitations including performing only exact matches ...
Bünning P, Holmquist B, Riordan JF (1978) Functional residues at the active site of angiotensin converting enzyme. Biochem Biophys Res Commun 83: 1442–1449 PubMed Google Scholar Bünning P, Holmquist B, Riordan JF (1983) Substrate specificity and kinetic characteristics of angiotensin converting...
ElliPro: a new structure-based tool for the prediction of antibody epitopes. BMC Bioinform. 2008;9:514. https://doi.org/10.1186/1471-2105-9-514. Article CAS Google Scholar Prager MD, Bachynsky N. Asparagine synthetase in normal and malignant tissues; correlation with tumor sensitivity to ...
EzCat-BLAST is suitable for quick searches, adopting the BLAST algorithm, whereas EzCat-FORTE is more suitable for detecting remote homologues, adopting the algorithm for FORTE protein structure prediction software. Another system, EzMetAct, is also available to searching for major active-site ...