The ab initio methods for catalytic site prediction exploit some of the known properties of active sites: active sites are usually found buried within a cleft of a protein, mutations in them can often increase the stability of an enzyme and they are highly conserved. This has led to the use...
5.33.6.2Metabolite Prediction Programs Metabolism is essentially a series of chemical reactions, each with a substrate and products. A computer system capable of recognizing chemical structures and portraying the products of metabolism is an ideal tool to support drug research and development. The requi...
We have predicted 606110 active site residues, of which 94% are not found in UniProtKB, and have increased the active site annotations in Pfam by more than 200 fold. Although implemented for Pfam, the tool we have developed for transferring the data can be applied to any alignment with ...
Capacity planning is a prediction, not a perfectly correct value, so don't expect it to be perfectly accurate. Always remember to adjust capacity as needed and constantly validate that your environment is working as intended. Data collection summary tables The following tables list and...
Toole DR, Zhao J, Martens-Habbena W, Strauss SL. Bacterial functional prediction tools detect but underestimate metabolic diversity compared to shotgun metagenomics in southwest Florida soils. Appl Soil Ecol. 2021;168: 104129. Article Google Scholar Sun S, Jones RB, Fodor AA. Inference-based...
Fig. 1: Overview of phage-assisted active site-directed ligand evolution. aA diagram that illustrates the interaction between a protein target and a ligand.bThe genetic incorporation of a ligand-fused ncAA into phage-displayed peptides for active site-directed binding to a protein target that is...
(Fig.3a). This strategy allowed us to trace fine apical tuft dendrites to their parent somata, map their receptive fields and, finally, image the tuft dendrites at a high magnification during visual stimulation (Fig.3band Extended Data Fig.4a). To test our prediction, we displayed sinusoidal...
SwissTargetPrediction (http://new.swisstargetprediction.ch) and Traditional Chinese Medicine Systems Pharmacology (TCMSP) databases were utilized to retrieve the potential targets of active ingredients. After removing repeating targets from the two databases, we obtained the potential targets of CO. ...
Radioactive Waste Management NEA Sorption Project Phase II: Interpretation and Prediction of Radionuclide Sorption onto Substrates Relevant for Radioactive Waste Disposal Using Thermodynamic Sorption Models (Complete Edition ‐ ISBN 9264... This report presents the results of Phase II of the NEA Sorption...
A current obstacle to high throughput applications of CRISPR/Cas9 is the imprecise prediction of highly active single guide RNAs (sgRNAs). We previously ... S Gandhi,M Haeussler,F Razy-Krajka,... - 《Developmental Biology》 被引量: 0发表: 2017年 Highly efficient CRISPR/Cas9-mediated knock-...