Requirements of Six binding sites for the activities of some but not all tested mesodermal enhancers.Brian W. BusserStephen S. GisselbrechtLeila ShokriTerese R. TanseyCaitlin E. GambleMartha L. BulykAlan M. Michelson
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We also developed a tool that further allows users to define tissue-specific enhancers by setting the threshold score of tissue specificity of enhancers. In addition, links to external resources are also available at EnhancerDB. 展开 关键词: GENE enhancers BINDING sites TRANSCRIPTION factors CELL ...
Enhancers, as a class of non-coding DNA regulatory elements, are composed of clusters of transcription factor (TF) binding sites and specifically regulate the expression of their target genes through enhancer-promoter interactions. Whole genome sequencing methods have shown that more than two million ...
Enhancers, as a class of non-coding DNA regulatory elements, are composed of clusters of transcription factor (TF) binding sites and specifically regulate the expression of their target genes through enhancer-promoter interactions. Whole genome sequencing methods have shown that more than two million ...
in AD. In addition, CpG sites are not the sole location at which DNA methylation occurs. In human neurons, a large proportion of methylation occurs at non-CpG sites (CpH)27, yet the role of these non-canonical methylation sites in AD is unknown. Hence, in this study we perform a ...
Multiple spatially specific enhancers are required to reconstruct the pattern of Hox-2.6 gene expression. Murine Hox genes are organized into four clusters that share many features with the homeotic clusters of Drosophila. This evolutionary conservation and the......
For example, BRD3 is attracted to a subset of estrogen receptor alpha binding sites (ERBSs) enriched with functional enhancer characteristics, found in groups of ERBSs that probably serve as "SEs" and are connected to genes with high E2-responsiveness. Furthermore, the clusters of ERBSs ...
human [40] and 35% are not even shared with the rat [54]. Third, not all TEs contribute equally: for any given TF, there is generally one or a few TE families that account for a disproportionate fraction of binding sites relative to their frequency in the genome [20,44,46,48,50,...
Native GATA and ETS (FGF) binding sites contain imperfect matches to consensus motifs. Perfect matches mediate robust but ectopic patterns of gene expression. The native sites are not arranged at optimal intervals, and subtle changes in their spacing alter enhancer activity. Multiple tiers of ...