All these conditions trigger stress in endoplasmic reticulum (ER) and in that way can disturb the protein quality control in retinal pigment epithelial (RPE) cells. ER stress stimulates the unfolded protein response (UPR) via the activation of IRE1, PERK and ATF6 transducers. The UPR signaling...
Endoplasmic reticulum stress signaling and chemotherapy resistance in solid cancers. Oncogenesis 6, e373 (2017). CAS PubMed PubMed Central Google Scholar Lee, E., Nichols, P., Groshen, S., Spicer, D. & Lee, A. S. GRP78 as potential predictor for breast cancer response to adjuvant ...
Protein folding in the endoplasmic reticulum (ER) is essential for proper cellular function. However, the sensitive environment in the ER can be perturbed by both pathological processes as well as by physiological processes such as a large biosynthetic load placed on the ER. ER stress is a speci...
Aging is associated with an increased risk of myocardial ischemia/reperfusion injury (IRI). With an increasing prevalence of cardiovascular diseases such as coronary arteriosclerosis in older people, there has been increasing interest in understanding th
Endoplasmic Reticulum Stress Signaling in Pancreatic β-Cells. Pancreatic β-cells are specialized for the production and regulated secretion of insulin to control blood-glucose levels. Increasing evidence indicates th... SG Fonseca,KL Lipson,F Urano - 《Antioxidants & Redox Signaling》 被引量: 46...
Endoplasmic reticulum stress signaling in disease. Physiol. Rev. 86, 1133–1149 (2006). CAS PubMed Google Scholar Ron, D. & Walter, P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat. Rev. Mol. Cell Biol. 8, 519–529 (2007). CAS PubMed Google Scholar ...
Endoplasmic Reticulum Stress: Signaling the Unfolded Protein Response. The endoplasmic reticulum (ER) is the cellular site of newly synthesized secretory and membrane proteins. Such proteins must be properly folded and posttra... E Lai - 《Physiology》 被引量: 758发表: 2007年 Free Cholesterol-load...
Its importance towards stress recognition and response relies on complex signaling processes that have evolved in eukaryotic organisms. Regardless of the intense research that has focused in the signaling pathways of the ER and its involvement in disease onset, it is clear that no universal biomarker...
Sensing stress within the endoplasmic reticulum (ER), the ER transmembrane protein IRE1α initiates a signal transduction pathway to restore homeostasis. A study finds that this process requires an ER membrane-bound phase separation event that leads to the local assembly of stress granules (SGs) an...
Recently, endoplasmic reticulum stress signaling has become a central mechanism in rosacea pathogenesis. In this review, we briefly summarize the current topics in rosacea pathogenesis, focusing on endoplasmic reticulum stress signaling and the lipid mediator sphingosine-1-phosphate. 展开 ...