Endoplasmic Reticulum Stress Mediates Palmitic Acid‐induced Insulin Resistance in Skeletal Muscle CellsPathological elevation of plasma fatty acids reduces insulin sensitivity. We found that insulin-stimulated phosphorylation of Akt was reduced by palmitic acid (PA). The same treatment also increased ...
Yoneda T, Imaizumi K, Oono K,et alActivation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stressJ Biol Chem2001;276: 13935-13940. Google Scholar Rao RV, Hermel E, Castro-...
The endoplasmic reticulum is an important intracellular organelle that plays an important role in maintaining cellular homeostasis. Endoplasmic reticulum stress (ERS) and unfolded protein response (UPR) are induced when the body is exposed to adverse external stimuli. It has been established that ERS c...
Here, we show that endoplasmic reticulum (ER) stress triggered by Aβ promotes cholesterol synthesis and mitochondrial cholesterol influx, resulting in mitochondrial glutathione (mGSH) depletion in older age amyloid precursor protein/presenilin-1 (APP/PS1) mice. Mitochondrial cholesterol accumulation was ...
The endoplasmic reticulum is an important intracellular organelle that plays an important role in maintaining cellular homeostasis. Endoplasmic reticulum stress (ERS) and unfolded protein response (UPR) are induced when the body is exposed to adverse ext
Tribbles 3 mediates en- doplasmic reticulum stress-induced insulin resistance in skeletal muscle. Nat Commun. 2013;4:1871.Koh HJ, Toyoda T, Didesch MM, et al. Tribbles 3 mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle. Nat Commun 2013; 4: 1871....
Endoplasmic reticulum stress mediates sulforaphane-induced apoptosis of HepG2 human hepatocellular carcinoma cells Mol. Med. Rep., 15 (2017), pp. 331-338 CrossrefView in ScopusGoogle Scholar [149] Y. Wang, Y. Xie, J. Ma, R. Gong, Z. Yan, W. Wang, Y. Wang, B. Xu, X. Li Lovast...
Endoplasmi reticulum stress is induced by a variety of stressors including misfolded proteins, this leads to a classic stress response and activation of X Box Binding Protien-1 (XBP-1) and ATF-6. This is induced in a variety of situations from multiple stressors and is a conserved pathway...
Endoplasmic reticulum stress mediates the neurotoxic effect of misfolded proteins in neurodegenerative diseases; 内质网应激介导神经变性疾病错折叠蛋白的神经毒性 3. Expression ofendoplasmic reticulummolecular chaperone GRP94 in Keloid; 内质网分子伴侣GRP94在瘢痕疙瘩中的表达 ...
Endoplasmic reticulum stress (ERS) can trigger various modes of cell death by activating the unfolded protein response (UPR) signaling pathway. Cell death plays a crucial role in the occurrence and development of diseases such as cancer, liver diseases, neurological diseases, and cardiovascular ...