which is involved in the post-translational regulation of transactivation activity of lignin-associated transcriptional repressors PtoMYB221 and PtoMYB156. PtoUBC34 is localized at the endoplasmic reticulum (ER) membrane where it interacts with transcriptional repressors PtoMYB221 and PtoMYB156....
ReZolve-ER localised to the nuclear membrane/endoplasmic reticulum (ER) and allowed the detection of exocytotic events at the plasma membrane. Thus, we present a new imaging agent for monitoring live cell events in real time, which is ideal for imaging either short or long time courses. This...
Full size image The impact of endoplasmic reticulum stress core genes on immune infiltration deserves attention The expression of six ERSRGs between HCC and normal tissues was deeply investigated in Fig. 6A. The results showed that there were significantly higher expression levels of CLGN, PPP1R16A...
ER, endoplasmic reticulum–retained podocin mutants; V, vesicular podocin mutants; PM, plasma membrane localized podocin mutants. Interestingly, we observed three specific bands for both Podwt and PodR138Q on podocin immunoblots. The fastest migrating band (lower band) was predominantly observed in ...
Persistent endoplasmic reticulum (ER) stress is thought to drive the pathology of many chronic disorders due to its potential to elicit aberrant inflammatory signaling and facilitate cell death. In neurodegenerative diseases, the accumulation of misfolde
Calnexin (Cnx) and calreticulin (Crt), which are important chaperones in the endoplasmic reticulum (ER), participate in the folding and quality control of client proteins. Cnx and Crt identified from Chinese mitten crab (Eriocheir sinensis) are designate
We have now applied DiPIUS to the F-box protein Fbxw7 in three cell lines (mHepa, Neuro2A, and C2C12) and thereby identified myelin regulatory factor (MyRF), an endoplasmic reticulum–anchored transcription factor that is essential for myelination of nerves in the central nervous system, as...
Lnc-MGC is regulated by an endoplasmic reticulum (ER) stress-related transcription factor, CHOP. Cluster microRNAs and lnc-MGC are decreased in diabetic Chop À / À mice that showed protection from DN. Target genes of megacluster microRNAs have functions related to protein synthesis and ER ...
Real-time PCR was used to examine expression of endoplasmic reticulum stress genes, viz. calreticulin (CRT), glucose-regulated protein-78 (GRP78) and endoplasmic reticulum protein-29 (ERp29), in the human leukemic cell culture. RNA was isolated from HL-60 cell culture using RNA extraction kit...
Consequently, hepatic Mfn2 deficiency reduces PS transfer and phospholipid synthesis, leading to endoplasmic reticulum (ER) stress and the development of a NASH-like phenotype and liver cancer. Ablation of Mfn2 in liver reveals that disruption of ER-mitochondrial PS transfer is a new mechanism ...