Mayer, Melissa. "Endoplasmic Reticulum (Rough & Smooth): Structure & Function (With Diagram)"sciencing.com, https://www.sciencing.com/endoplasmic-reticulum-rough-smooth-structure-function-with-diagram-13717290/. 15 March 2019. APA Mayer, Melissa. (2019, March 15). Endoplasmic Reticulum (Rough &...
Endoplasmic reticulum stress may be intertwined with a molecular cascade of responses such as mitochondrial dysfunction, oxidative stress, neuroinflammation, autophagy, and cell death, which together influence the progression of traumatic brain injury. Moderate endoplasmic reticulum stress can be protective, ...
Accelerating Ascorbic Acid Turnover Diego Pozzer1, Mariagrazia Favellato1, Marco Bolis1, Roberto William Invernizzi1, Francesca Solagna2, Bert Blaauw2,3 & Ester Zito4 Endoplasmic reticulum (ER) and oxidative stress are two related phenomena that have important metabolic consequences...
Protocol Name: Confirmatory qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: secreted ER Calcium Modulated Protein (SERCaMP) assay Pubchem AID 1508628 Protocol Name: Cell Viability qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome Pubchem...
gp96 (grp94, HSP90b1) is an endoplasmic reticulum master chaperone for multiple TLRs. We report herein that gp96 is also essential for expression of 14 hematopoietic system-specific integrins. Genetic deletion of gp96 thus enables us to determine the collective roles of gp96, integrins, and ...
Tumor cells display augmented capability to maintain endoplasmic reticulum (ER) homeostasis and hijack ER stress pathway for malignant phenotypes under microenvironmental stimuli. Metabolic reprogramming is a well-known hallmark for tumor cells to provid
Here, we show that reticulon 4B (Nogo-B), an endoplasmic reticulum (ER)-resident protein, interacts with the major proglucagon fragment of proglucagon to retain proglucagon on the ER, thereby inhibiting PCSK1-mediated cleavage of proglucagon in the Golgi. Intestinal Nogo-B knockout in male type...
The integrated stress response (ISR) converges on eIF2α phosphorylation to regulate protein synthesis. ISR is activated by several stress conditions, including endoplasmic reticulum (ER) stress, executed by protein kinase R-like endoplasmic reticulum kinase (PERK). We report that ER stress combined ...
Herein the effect of curcumin on endoplasmic reticulum (ER) stress responsive gene expression was investigated. We report that curcumin induces transcriptional corepressor small heterodimer partner-interacting leucine zipper protein (SMILE) gene expression through liver kinase B1 (LKB1)/adenosine monophosphate...
ERX-41 induces endoplasmic reticulum (ER) stress resulting in cell death, and this effect is on target as evidenced by specific LIPA mutations providing resistance. Importantly, we demonstrate that ERX-41 activity is independent of LIPA lipase function but dependent on its ER localization. ...