Mayer, Melissa. "Endoplasmic Reticulum (Rough & Smooth): Structure & Function (With Diagram)"sciencing.com, https://www.sciencing.com/endoplasmic-reticulum-rough-smooth-structure-function-with-diagram-13717290/. 15 March 2019. APA Mayer, Melissa. (2019, March 15). Endoplasmic Reticulum (Rough &...
Endoplasmic reticulum stress may be intertwined with a molecular cascade of responses such as mitochondrial dysfunction, oxidative stress, neuroinflammation, autophagy, and cell death, which together influence the progression of traumatic brain injury. Moderate endoplasmic reticulum stress can be protective, ...
aRepresentative confocal images of primary microglia untreated (Control) or treated with ATP (1 mM) fromP2X7R−/−mice stained for nuclei (Hoechst 33342, blue), endoplasmic reticulum (ER-Tracker, green), and mitochondria (Mito-Tracker, red, left panel) and quantification of the colocalizat...
ER, endoplasmic reticulum; BH, BCL-2 homology; BIK, BCL-2 interacting killer; MAM, mitochondria-associated ER membrane; MBR, membrane-binding region; MIM, mitochondrial inner membrane; MOM, mitochondrial outer membrane. The prediction largely agrees with that originally published by McDonnell et al...
Aortic dissection (AD) poses a significant threat to cardiovascular health globally, yet its underlying mechanisms remain elusive. Smooth muscle cells death and phenotypic switching are critically important pathological processes in AD. Currently, no pha
Mutants affecting the structure of the cortical endoplasmic reticulum in Saccharomyces cerevisiae J. Cell Biol, 150 (2000), pp. 461-474 View in ScopusGoogle Scholar 48 X. Wang, L. Huang Identifying dynamic interactors of protein complexes by quantitative mass spectrometry Mol. Cell. Proteomics, 7...
The integrated stress response (ISR) converges on eIF2α phosphorylation to regulate protein synthesis. ISR is activated by several stress conditions, including endoplasmic reticulum (ER) stress, executed by protein kinase R-like endoplasmic reticulum kinase (PERK). We report that ER stress combined ...
The ER is an important organelle for protein synthesis, folding, and secretion in eukaryotic cells. ER stress is a kind of cellular stress state caused by protein folding dysfunction of the endoplasmic reticulum that is induced endogenously or exogenously. The expression of ER stress markers, includ...
gp96 (grp94, HSP90b1) is an endoplasmic reticulum master chaperone for multiple TLRs. We report herein that gp96 is also essential for expression of 14 hematopoietic system-specific integrins. Genetic deletion of gp96 thus enables us to determine the collective roles of gp96, integrins, and ...
The formation of disulfide bonds in the endoplasmic reticulum (ER) of eukaryotic cells is catalyzed by the sulfhydryl oxidase, ER oxidoreductin 1 (Ero1), and protein-disulfide isomerase (PDI). PDI is oxidized by Ero1 to continuously introduce disulfides into substrates, and feedback regulates ...