Moreover, its low apparent Ca2+affinity, when compared with SERCA1 or SERCA2 (19, 24) suggests that it has a unique function or that it is located in a unique compartment. In many of the cell types in which SERCA3 is expressed, Ca2+signaling pathways are involved in transducing a ...
In total, 89% of investigated wolves carried endoparasites. Differences in the helminth fauna of all 53 individuals as a function of their geographic origin are depicted inFig. 2. The cestodeT. hydatigenaoccurred significantly less frequently in ‘natives’ born in Germany (3%) than in ‘immig...
Protein Function domain:C-type lectin domains 3 to 8 are not required for calcium-dependent binding of mannose, fucose and N-acetylglucosamine. C-type lectin domain 2 is responsible for sugar-binding in a calcium-dependent manner.,domain:Fibronectin type-II domain mediates collagen-binding.,domain...
Cytosine deamination into uracil is one of the most prevalent and pro-mutagenic forms of damage to DNA. Base excision repair is a well-known process of uracil removal in DNA, which is achieved by uracil DNA glycosylase (UDG) that is found in all three domains of life. However, other strat...
The limitations of this study include the cross-sectional design and inability to show causality for any of our associations. Other thanFLGmutations, all biological markers measuring skin barrier function and type 2 inflammation can vary quite rapidly; thus, we were unable to determine whether these...
further suggesting that the enzyme can modulate genome stability by facilitating the resolution of R-loops. However, it remains unknown how FEN1 can process RNA to resolve an R-loop. In this study, we examined the FEN1 cleavage activity on the RNA:DNA hybrid intermediates generated during DNA...
These changes were accompanied by involution of the thymus. Thus, the varied data indicate persistent increased metabolism and adrenocortical activity during the life-span of the whirler mice. Seminal vesicle weight decreases in the whirler males at 11 months suggest lower gonadal function. The ...
STUDIES ON THYROID FUNCTION IN THE MOUSE: INTERSTRAIN DIFFERENCES IN THYROXINE SECRETION RATES AND ORGAN CONTENT OF THYROXINEThyroxine secretion rates and thyroxine concentration in various organs (liver, spleen, intestines, kidneys, heart and thymus) have been estimated in five strains of mice by a...
The histophysiological changes observed in the adrenal cortex of breeder rats are believed to be analogous to conditions seen in humans with hyperadrenocorticism or Cushing's disease. It is suggested that there may be a close correlation between the abnormal adrenal function engendered by repeated ...