An abnormal chromosome produced during mitosis or meiosis that is characterized by the presence of two genetically and morphologically identical chromosome arms fused at the centromere. Strictly, the common alteration of chromosome 17 in medulloblastoma is more often an isodicentric (17q), as the brea...
Meiosis Specialized type of reductive cell division. Microhomology-mediated end joining End joining of a DSB that is Lig4 independent and relies on small homologies (4–8nt) of the broken ends for ligation and repair. Mitosis Nonreductive cell division. ...
Because error-free HR is impaired in BRCA1- and BRCA2-deficient cells15,16, it is likely that error-prone repair of HR substrates are causal for the mutations observed in these tumours. It is often postulated that in the absence of HR, DNA double-strand breaks are repaired via non-homolo...
These G4 variants are speculated to have biological roles ranging from the inhibition of telomerase activity [34] and protection of chromosome ends [35] to mediating chromosome arrangement during meiosis and mitosis [30,36]. Formation of G-quadruplex structures in vivo at telomeres was Genes 2019...
NCAPG is a subunit of the condensin complex that encodes a cohesive complex and is responsible for chro mosomal cohesion and stability during the process of mitosis and meiosis. As per previous research investiga tions, NCAPG is also involved in distinct tumor types. In the current ...
Living cells devise mechanisms that minimize DNA damage. Such mechanisms include base excision repair, non-homologous-end joining, and homologous recombinational repair.
Ianzini F, Kosmacek EA, Nelson ES, Napoli E, Erenpreisa J, Kalejs Met al. Activation of meiosis-specific genes is associated with depolyploidization of human tumor cells following radiation-induced mitotic catastrophe.Cancer Res2009;69: 2296–2304. ...