An abnormal chromosome produced during mitosis or meiosis that is characterized by the presence of two genetically and morphologically identical chromosome arms fused at the centromere. Strictly, the common alteration of chromosome 17 in medulloblastoma is more often an isodicentric (17q), as the brea...
Failure to preserve the integrity of the genome is a hallmark of cancer. Recent studies have revealed that loss of the capacity to repair DNA breaks via homologous recombination (HR) results in a mutational profile termed BRCAness. The enzymatic activity that repairs HR substrates in BRCA-deficien...
These G4 variants are speculated to have biological roles ranging from the inhibition of telomerase activity [34] and protection of chromosome ends [35] to mediating chromosome arrangement during meiosis and mitosis [30,36]. Formation of G-quadruplex structures in vivo at telomeres was Genes 2019...