The kinetics of angiotensin converting enzyme (ACE) inhibition by captopril (SQ 14225) and enalapril (MK 421) in anesthetized rabbits was investigated. Kinetic parameters, apparent Km, an index of enzyme-substrate affinity and apparent Vmax, a measure of maximal rate of substrate conversion, were ...
A comparison of captopril with enalapril. The Quality-of-Life Hypertension Study Group. BACKGROUND: We conducted a multicenter trial comparing two angiotensin-converting-enzyme inhibitors to determine whether effects on quality of life during ... MA Testa,RB Anderson,JF Nackley,... - 《N Engl ...
(MK-421) is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Enalapril may be used to treat essential ...
Captopril, enalapril, lisinopril, perindopril and ramipril all appear to precipitate severe angioneurotic oedema in some patients, and appropriate warnings are given in the data sheets (26, 28, 30–32). Drug interactions with ACE inhibitors
(1-7) | Captopril | Diminazene aceturate | DX600 TFA | Lisinopril dihydrate | Omapatrilat | Sinapinic acid | Perindopril erbumine | Fosinopril sodium | Ramipril | Resorcinolnaphthalein | Enalaprilat dihydrate | Benazepril hydrochloride | Quinapril hydrochloride | Trandolapril | Deserpidine | ...
Hepatic dysfunction also slows the conversion of enalapril and quinapril to their active metabolites. There is evidence that both captopril and enalapril, but not quinapril, may accumulate with repeated dosing. The pharmacokinetics of these agents are not significantly modified by co-administration of ...