There are some noteworthy distinctions between enalapril and captopril and lisinopril. Lisinopril is hydrophilic, has a lengthy half-life, and is not metabolized by the liver. The angiotensin-converting enzyme is competitively inhibited by lisinopril (ACE). The US Food and Drug Administration (FDA) ...
▪Breastfeeding SafetyThere is no published experience in nursing women. It is unknown whetherlisinoprilenters human breast milk. Other ACEIs (e.g.,captopril) are excreted in the milk at low concentrations. ▪Drug Interactions Patients on diuretics, especially those recently started, may occasional...
Enalapril, the ethyl ester of enalaprilat, exhibited little cross-reactivity (0.005%), and several other compounds (captopril, proline, lysine, tyrosine, hippuric acid, and tryptophan) were found not to cross-react. In rabbits given a 2.03 mol/kg iv dose of enalapril, plasma concentrations of...
(1-7) | Captopril | Enalapril maleate | MLN-4760 | Perindopril erbumine | Benazepril hydrochloride | Phosphoramidon Disodium | Diminazene aceturate | Quinapril hydrochloride | Cilazapril monohydrate | Enalaprilat dihydrate | Fosinopril sodium | Trandolapril | Ramipril | Moexipril hydrochloride | Omap...
Another angiotensin-converting enzyme inhibitor, captopril, has been shown to cause agranulocytosis and bone marrow depression, rarely in uncomplicated patients but more frequently in patients with renal impairment, especially if they also have a collagen vascular disease. Available data from clinical tri...
Captopril | Talfirastide | MLN-4760 | (Z)-Guggulsterone | Enalapril maleate | Diminazene aceturate | Ramipril | Sinapinic acid | BMS-265246 | Lisinopril | Peimisine | Enalaprilat dihydrate | Perindopril erbumine | Plantainoside D | Alamandine | Benazepril hydrochloride | Omapatrilat | Resorcinol...
to yield an activediacidinhibitor,enalaprilat. AllACE inhibitors, exceptlisinopriland captopril, are administered in their prodrug form so as to improve absolute bioavailability.4It was initially thought that prodrug conversion of an ACE inhibitor to an active diacid form would be curtailed in the ...