2. Enalapril Oral Solution Dosage and Administration 2.2 Heart Failure The recommended initial dose is 2.5 mg twice a day titrated up to a maximum of 20 mg twice a day, as tolerated. Doses are usually given in combination with diuretics and digitalis. In patients with hyponatremia (serum sodi...
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Enalapril was associated with an increasing dose-response relationship across the 2.5-40 mg/day range. The 2.5 mg/dose is effective in some patients; however, doses greater than or equal to 10 mg/day may be necessary to achieve satisfactory blood pressure control....
Basal nitric oxide synthesis of the renal vasculature was assessed by the decrease in RPF after inhibition of nitric oxide synthase with N[sup G]-monomethyl-L-arginine (L-NMMA; 4.25 mg/kg). Results: After one week of therapy, the combination therapy decreased ...
+/- 1 mmHg, nifedipine alone (30 mg/d) lowered supine blood pressure by 11 +/- 2/8 +/- 1 mmHg and there was a positive interactive effect of 10 +/- 3/7 +/- 2 mmHg (P less than 0.001) such that the combination lowered supine blood pressure by 32 +/- 3/24 +/- 2 mmHg....
In this open﹍abel, randomized 3﹚ay crossover study, 24 healthy subjects received a 10﹎g enalapril dose administered as (1) 2 × 5﹎g tablets of the RP swallowed with water, (2) 10 × 1﹎g ODMT swallowed with water, and (3) 10 × 1 mg ODMT dispersed on the tongue. When the...
The patients were treated for at least three years, and initially received 240 mg/day of verapamil (N = 24, group I), 5 mg/day of enalapril (N = 24, group II) or 1 mg/day of doxazosin (N = 40, group III). Baseline creatinine did not differ in the three groups, but ...
(4.2 L/h), n = 12], moderate renal impairment [group 2, CLCR 30 to 70 ml/min (1.8 to 4.2 L/h), n = 12] or severe renal impairment [group 3, CLCR < 30 ml/min (1.8 L/h), n = 12] received a single oral dose of either temocapril 1 mg (n = 6, each group) or ...
A total of 891 patients with sitting diastolic blood pressure (SiDBP) between 95 and 115 mm Hg were randomly assigned to enalapril 5 mg, diltiazem ER 120 mg, diltiazem ER 180 mg, enalapril 5 mg/diltiazem ER 120 mg (E5/D120), enalapril 5 mg/diltiazem ER 180 mg (E5/D180), or ...
Enalapril reduced blood pressure at dosages of 2.5 or 5 mg/day, and these dosages were lower than in patients with normal renal function (5 to 10 mg/day). In contrast, temocapril showed hypotensive effects at dosages of 2 or 4 mg/day, almost the same as in patients with normal ...