品系描述 将IRES-Cre插入到小鼠Emx1基因终止密码子处。 应用领域:Cre工具,88%的大脑皮层和海马神经元,大脑皮质神经胶质细胞等区域 *使用本品系发表的文献需注明: Emx1-IRES-Cre mice (Cat. NO. NM-KI-200149) were purchased from Shanghai Model Organisms Center, Inc.. ...
将IRES-Cre插入到小鼠Emx1基因终止密码子处。 应用领域:Cre工具,88%的大脑皮层和海马神经元,大脑皮质神经胶质细胞等区域 *使用本品系发表的文献需注明: Emx1-IRES-Cre mice (Cat. NO. NM-KI-200149) were purchased from Shanghai Model Organisms Center, Inc.. ...
Our results suggest that Emx1 is not expressed in every neuron in the developing and adult cerebral cortex. This line of cre mice should contribute to the studies of cortical development and plasticity. 展开 关键词: cerebral cortex hippocampus Cre/loxP transgenic mice Emx1 knock-in reporter mice...
We reported previously the creation of a line of transgenic mice in which the cre gene was placed directly downstream of the putative Emx1 promoter using ES cell technology. We showed that Cre protein was present in the cerebral cortex of the transgenic mice and was able to mediate loxP-...
Hypomyelination Phenotype Caused by Impaired Differentiation of Oligodendrocytes in Emx1-cre Mediated Cdk5 Conditional Knockout Mice Cyclin-dependent kinase 5 (Cdk5) plays a pivotal role in neuronal migration and differentiation, and in axonal elongation. Although many studies have been ... X He,S ...
Additionally, chemogenetic activation induced social deficits in Emx1-Cre mice. CRHR1 expression increased in the hippocampus of Emx1-Cre;IRSp53 flox/flox mice, and CRHR1 was reduced by chemogenetic inhibition. Htd2, Ccn1, and Atp61l were decreased in bulk RNA sequencing, and Eya1 and Ecr...
While SMN expression was robust in the central nervous system as expected, SMA mice did not live longer. Weight and time-to-right motor function were not significantly improved.doi:10.1007/s11248-013-9702-yAlexander S. TaylorJacqueline J. Glascock...
However, the spatiotemporal differences in Cre recombinase activity would lead to divergent phenotypes. Here, we compared the patterns of Cre activity in the early embryos among the three lines by mating with reporter mice. The activities of Emx1IRES-Cre, D6-Cre and hGFAP-Cre were observed ...
Hypomyelination phenotype caused by impaired differentiation of oligodendrocytes in Emx1-cre mediated Cdk5 conditional knockout mice. He Xiaojuan,Takahashi Satoru,Suzuki Hiromi,Hashikawa Tsutomu,Kulkarni Ashok B,Mikoshiba Katsuhiko,Ohshima Toshio. Neurochemical Research . 2011...
Mice, Mutant StrainsAmygdalaTelencephalonBasal GangliaCerebral CortexNeurogliaNeuronsInterneuronsBy homologous recombination of an internal ribosome entry site and Cre recombinase coding region into the 3'-untranslated region of the mouse Emx1 gene, we have generated a strain of ...