Alterations in gene sequences, expression levels and protein structure or function have been associated with every type of cancer. These 'molecular markers' can be useful in detecting cancer, determining prognosis and monitoring disease progression or th
Alterations in gene sequences, expression levels and protein structure or function have been associated with every type of cancer. These 'molecular markers' can be useful in detecting cancer, determining prognosis and monitoring disease progression or therapeutic response. But what is the best way to...
Alterations in gene sequences, expression levels and protein structure or function have been associated with every type of cancer. These 'molecular markers' can be useful in detecting cancer, determining prognosis and monitoring disease progression or therapeutic response. But what is the best way to...
Available and emerging molecular markers in the clinical management of breast cancerBreast cancerbiomarkersrisk of recurrencecell-free DNAtargeted therapypersonalized medicineIntroduction: Biomarker assessment is fundamental to managing patients with invasive breast cancer. While the assessment of estrogen ...
Cancer 1. Introduction In the early 1990s, X-box binding protein 1 (XBP1) was first discovered by cloning; it was characterized as a unique basic-region leucine zipper (bZIP) transcription factor involved in the regulation of human MHC class II gene expression [1]. Approximately a decade late...
in triple-negative breast cancer (TNBC) cells by inhibiting CMTM6 [50]. The circular RNA hsa_circ_0067842 interacts with HuR, improving the stability of CMTM6 by influencing nuclear translocation. CMTM6, in turn, regulates the ubiquitination of PD-L1 and inhibits its degradation [51]. (Fig....
In recent years, there has been an explosion of novel targeted immunotherapies for advanced cancers. In the present manuscript, we explore known and potential various types of cancer prevention strategies and focus on nonvaccine-based cancer preventive strategies targeting the immune system at the ...
Exosomal circRNA serves a novel genetic information molecule, facilitating communication between tumor cells and microenvironmental cells, such as immune cells, fibroblasts, and other components, thereby regulating critical aspects of cancer pr
As a member of heat shock protein 70 (HSP70) superfamily, glucose regulated protein 78 (GRP78) has been documented as a molecular chaperone in the endoplasmic reticulum (ER) which mainly responds to ER stresses in normal cells. There is over-expression of GRP78 on the surface of cancer ...
molecular pathways involved in ovarian carcinogenesis has led to the discovery and evaluation of several novel molecular targeted agents, with the aim to test alternative models of treatment in order to overcome the clinical problem of resistance. in this context the study of ovarian cancer stem ...