3. Pathogenic mechanisms of S100A8/A9 in sepsis 4. The roles of S100A8/A9 in sepsis-induced organ injury 5. Prospects of S100A8/A9 as a clinical biomarker and therapeutic target in sepsis and sepsis-induced organ injury 6. Conclusion Funding CRediT authorship contribution statement Declaration ...
Prognostic markers Translational research This article is cited by CINC-2 and miR-199a-5p in EVs secreted by transplanted Thy1+ cells activate hepatocytic progenitor cell growth in rat liver regeneration Norihisa Ichinohe Naoki Tanimizu Toshihiro Mitaka ...
brown adipose tissue (BAT) has been demonstrated to play a critical role in controlling energy and glucose homeostasis, which is associated with peripheral insulin resistance [27,28]. However, white adipose tissue (WAT), particularly visceral WAT in the trunk, upper body,...
As commented, the initial mechanism leading to PH is the IHVR to portal blood flow. This is due to a combination of structural changes and increased vascular tone. The structural component is determined by progressive fibrosis, vascular occlusion with ensuing parenchymal extinction and tissue collapse...
Molecular Methods Performed on Positive Blood Culture Bottles Rapid identification and antimicrobial susceptibility testing (AST) for bloodstream pathogens are critical in transitioning empiric to directed antimicrobial therapy, a key step in optimizing patient outcomes in the setting of sepsis. In traditional...
Numerous studies have shown histological and biochemical evidence of DIC during Ebola infection in a variety of nonhuman primate species including significant changes in markers of blood coagulation and fibrinolysis including various clotting fac- tors, FDPs, D-dimers, protein C, tissue plasminogen ...
EVs can also efficiently transit biological barriers, including blood vessels and the blood–brain barrier (BBB)—a critical feature for drug delivery vehicles92—to permit targeted or untargeted delivery of their therapeutic factors and thereby increase bioavailability across such barriers to reduce dos...
In humans, CD14 and CD15 have been suggested as markers for mMDSC and gMDSC, respectively, but further investigation is needed to verify this hypothesis[11]. The two subsets seem to differ in their suppressive capacity and functional mechanism(s) depending on the disease studied. As MDSC are...
are another class of glucose-lowering drugs with notable anti-inflammatory properties [178,179]. These drugs promote glucose excretion via the urine, thereby lowering blood glucose levels. Beyond their glycemic effects, SGLT-2 inhibitors have been associated with reductions in inflammatory markers, incl...
Kidney diseases remain one of the leading causes of human death and have placed a heavy burden on the medical system. Regulated cell death contributes to the pathology of a plethora of renal diseases. Recently, with in-depth studies into kidney diseases