Blood-derived biomarkers for brain and spinal cord diseases are urgently needed. The introduction of highly sensitive immunoassays led to a rapid increase in the number of potential blood-derived biomarkers for diagnosis and monitoring of neurological di
blood stream infectionMALDI-TOFmolecular diagnosticsnext-generation sequencingNGSPCRPCR/ESI-MSsepsisBloodstream (BSI) by microorganisms can lead to . This condition has a high mortality rate, which rises significantly with delays in initiation of appropriate antimicrobial treatment. Current culture methods ...
The KP factor(s) responsible for this phenotype is currently unknown. Evidence also establishes that in vivo KP infection induces subpopulations of neutrophils expressing markers characteristic of less active cells such as the immune checkpoint PD-L1, Siglec-H, and reduced levels of the activation ...
Topical treatment enhanced the healing rate of diabetic foot ulcers; however, did not decrease the bacterial wound burden nor key IL-1α and TNF- α inflammatory markers in a phase II trial36. It was proposed that bacterial resistance, production of LL-37 degrading proteases by pathogens such ...
Kidney diseases remain one of the leading causes of human death and have placed a heavy burden on the medical system. Regulated cell death contributes to the pathology of a plethora of renal diseases. Recently, with in-depth studies into kidney diseases
Genome instability biomarkers and blood micronutrient risk profiles associated with mild cognitive impairment and Alzheimer's disease - ScienceDirect Successful maintenance of metabolic systems relating to accurate DNA replication and repair is critical for optimal lifelong human health. Should this home......
Molecular Methods Performed on Positive Blood Culture Bottles Rapid identification and antimicrobial susceptibility testing (AST) for bloodstream pathogens are critical in transitioning empiric to directed antimicrobial therapy, a key step in optimizing patient outcomes in the setting of sepsis. In ...
Nowadays, blood donations are screened for various infectious agents in developed countries or regions where EID agents have been well studied. In the United States, the blood supply is routinely screened for Human T-lymphocyte virus (HTLV). West Nile virus (WNV); Trypanosoma cruzi [1], [2]...
(heparin, heparinoids, nature plasma proteins, small anion molecules and nanomedicines, etc.) or extracorporeal blood purification techniques can significantly alleviate histone-induced deleterious effects, and thus improve the outcomes of histone-related critical and inflammatory animal models. However, a ...
In addition, the vascular leakage that occurs during sepsis, which can result in injury of multiple organs, is associated with gene expression, metabolomic changes, and markers characteristic of ferroptosis (She et al., 2021). Sickle cell disease is associated with the accumulation of heme in ...