Sepsis, a potentially life-threatening complication of an infection, has the highest burden of death and medical expenses in hospitals worldwide. Leukocyte count and CD64 expression on neutrophils (nCD64) are known to correlate strongly with improved sen
For the purposes of diagnosis and prognosis in critical care, PCT has an advance over other traditional markers of sepsis. However, PCT is not widely adopted by clinicians due to its non-specificity28. In our current mouse models, we found that PCT did not respond to LPS injection until 24...
"We have for the first time identified a group of biomarkers in the blood that are good indicators of sepsis. We have shown that it is possible to detect these markers by screening a patient's blood in the ward, a process which can deliver results within two hours. This is an extremely...
A variety of quality criteria definitions exist for biomarker in general depending on the different application areas described above (Editorial2010). To meet endophenotype criteria, candidate markers have to be (1) heritable, (2) relatively state-independent and stable over time, (3) associated wit...
A solution to this problem is to find new markers for precise differential diagnosis between bacterial and viral infections and thereby guide the physician to avoid unnecessary antibiotic prescriptions. The current diagnostic strategies rely mainly on pathogen-based detection techniques, which suffer from ...
In dogs, mild changes in WBC counts and in markers of coagulation (activated partial thromboplastin time, fibrinogen, protein-C, and -S) were seen in peripheral blood in response to experimentally induced localized soft tissue inflammation [42]. Increased levels of for example serum IL-6, IL-...
For the time being, it appears that platelet-derived growth factor receptor-β (PDGFR-β) and nerve-glial antigen-2/chondroitin sulfate proteoglycan 4 (NG2) might serve as the most reliable markers for these cells (Navarro et al., 2016), though several other molecules have been found ...
The combination of multiple laboratory indicators for the prediction of inflammation is receiving increasing attention, as it can provide a more comprehensive reflection of the patient’s inflammatory status. Blood cell count-derived inflammatory markers (BCDIMs): NLR, MLR, PLR, LCR, SIRI and systemi...
Brain injuries Hypoxia Predictive markers This article is cited by Establishing a regional registry for neonatal encephalopathy: impact on identification of gaps in practice Mohamed El-Dib Hoda El-Shibiny Terrie Inder Pediatric Research (2024) A nomogram for predicting sepsis-associated delirium: a...
– , Markers of PMN activation were assessed pre-isolation and after inertial microfluidics or density-based gradient separation, namely the expression of CD11b (MFI; =4–6; ), CD66b (MFI; =4–6; ) and CD18 (percentage total PMN; =4; ). The values are expressed as the mean±s.e....