17脑心肌炎病毒(EMCV)的内部核糖体进入位点活性的研究 蔡燕飞 朱瑞宇 陈 蕴 金 坚 (江南大学医药学院药物设计与分子药理学实验室 无锡 214122)摘要 脑心肌炎病毒( Encephalomyocarditisvirus,EMCV) 的内部核糖体进入位点( internalribosomalentrysite,IRES)已被广泛运用于蛋白的表达中,如应用于Clontech 公司推出的 ...
ActivePhelan, MarieRamesh, Vasudevan
The role of IRES involves the recruitment of 40S ribosomal subunit and associated protein factors which are essential for translation to initiate. However, the tertiary structure and interactions of IRES is not known so far and therefore, the mechanism is...
S.PhelanM.RasulU.RameshV.ORGANIC AND BIOMOLECULAR CHEMISTRYMohammed, S., Phelan, M. M., Rasul, U., and Ramesh, V. (2014). NMR elucidation of the role of Mg2+ in the structure and stability of the conserved RNA motifs of the EMCV IRES element. Org. Biomol. Chem. 12, 1495-1509. ...