Elevated protein concentrations in newborn blood and the risks of autism spectrum disorder, and of social impairment, at age 10 years among infants born before the 28th week of gestation.doi:10.1038/S41398-018-0156-0Steven J. Korzeniewski...
Blood.1993;82:513-520.Google Scholar 41. Harris TB, Ferrucci L, Tracy RP. et al. Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am J Med.1999;106:506-512.Google Scholar 42. Gallagher D, Visser M, Sepúlveda D. et al. How useful...
We assessed if elevated protein synthesis in neurons leads to abnormal behaviors in mice. As revealed in rotarod and open-field tests (Supplementary Fig.2b, c), NN4Emice had intact motor function. We examined anxiety-like behaviors by performing open field, elevated plus maze, and light-dark ...
Indications for ordering an SPEP or UPEP are presented in Table 1. Table 1. Indications for Ordering Serum Protein Electrophoresis Elevated protein gap (total protein minus albumin >4.0 g/dL) Suspected multiple myeloma, Waldenstrom macroglobulinemia, primary amyloidosis, or related disorder Unexplained ...
We investigated vascular transformation biomarkers in Long-COVID patients. Methods A case–control study utilizing Long-COVID patients, one to six months (median 98.5 days) post-infection, with multiplex immunoassay measurement of sixteen blood biomarkers of vascular transformation, including ANG-1, P...
The deposition of aggregated amyloid-β peptides derived from the pro-amyloidogenic processing of the amyloid precurson protein (APP) into characteristic amyloid plaques (APs) is distinctive to Alzheimer’s disease (AD). Alternative APP processing via the metalloprotease ADAM10 prevents amyloid-β form...
High-intensity interval training (HIIT) has been found to be more effective in relieving heart failure (HF) symptoms, than moderate-intensity continuous aerobic training (MICT). Additionally, higher meteorin-like protein (Metrnl) levels are seen after HIIT versus MICT. We investigated whether Metrnl...
Here we show, using proteomics profiling to screen plasma from patients with suspected acute VTE, and several case-control studies for VTE, how Complement Factor H Related 5 protein (CFHR5), a regulator of the alternative pathway of complement activation, is a VTE-associated plasma biomarker. ...
Background Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are commonly used inflammatory markers utilized to aid in the diagnosis of periprosthetic infection. Patients with obesity, however, are known to have elevated baseline levels of these inflammatory markers. Therefore, this ...
Ser/Thr protein phosphatase 5 (PP5) regulates several signaling-cascades that suppress growth and/or facilitate apoptosis in response to genomic stress. The expression of PP5 is responsive to hypoxia inducible factor-1 (HIF-1) and estrogen, which have both been linked to the progression of human...