Elevated levels of CSF total protein correlate to IL-8, MCP-1, and Loes MRI severity score.Troy C., LundPaul, S. StademAngela, PanoskaltsisMortariGerald, RaymondWeston, P. MillerJakub, TolarPaul, J. Orchard
Objective To test whether overweight and obesity are associated with low-grade systemic inflammation as measured by serum C-reactive protein (CRP) level. Design and Setting The Third National Health and Nutrition Examination Survey, representative of the US population from 1988 to 1994. Participants ...
The deposition of aggregated amyloid-β peptides derived from the pro-amyloidogenic processing of the amyloid precurson protein (APP) into characteristic amyloid plaques (APs) is distinctive to Alzheimer’s disease (AD). Alternative APP processing via the metalloprotease ADAM10 prevents amyloid-β form...
To confirm the loss of BTH-induction of PR1 protein accumulation, western blot analysis using a PR1 antibody was also conducted with fractionated protein samples confirmed to have NPR1 localized to the nucleus. Similar toPR1gene expression (Fig.3a), PR1 protein was only detectable in BTH-treated ...
Equal amounts of total protein were separated by SDS-PAGE, transferred by Western blot analysis, and detected by immunostaining with the indicated antibodies (Abs). The anti-GFP antibody detects a cross-reactive band (asterisk) close to the StARD3 band (arrow). B: Fluorescence micrographs of ...
C-reactive protein (CRP) has been associated with disease progression in patients with osteoarthritis (OA), but the reasons for this remain unclear. We hypothesized that higher CRP would be related to local inflammatory findings in the joints of patients with OA. Plasma and synovial membrane speci...
In multivariate analyses, C-reactive protein (CRP) was the most important prognostic factor in this population, and vitamin B12 provided information independent of CRP in predicting survival. These data indicate that an elevated serum vitamin B12 level is a predictive factor for mortality in patients...
In addition to age, sex, and race, dietary intake of protein (in particular cooked meat) is an independent determinant of creatinine production. Second, increased tubular secretion of creatinine causes the rise in serum creatinine level to lag behind the decline in glomerular filtration rate. ...
C-D RT-qPCR and western blot were performed to detect the mRNA and protein level of METTL1 between HSPC and CRPC patients’ samples. E Immunohistochemistry (IHC) assay was carried out to determine the METTL1 expression on a tissue microarray (TMA). Objective magnification: 40X, 100X, and ...
The shelterin protein TRF2 is essential for chromosome-end protection. Depletion of TRF2 causes chromosome end-to-end fusions, initiating genomic instability that can be cancer promoting. Paradoxically, significant increased levels of TRF2 are observed i