In fact, IGFBP-2 is regulated not only by growth hormone [18] but to a significant extent also by sex steroids [19]. Under conditions of malignant growth, IGFBP-2 can increase estrogen receptor expression and the activity of the phosphatidylinositol 3-kinase (PI3K) as provided by Foulstone ...
structure, chemistry and function of the brain; moreover, these changes are superimposed on innate differences in brain anatomy, neurochemistry and function according to one's sex, as defined by reproductive organs (testes or ovaries) and sex chromosomes (XX in males, XY in females) [4,5]....