In fact, IGFBP-2 is regulated not only by growth hormone [18] but to a significant extent also by sex steroids [19]. Under conditions of malignant growth, IGFBP-2 can increase estrogen receptor expression and the activity of the phosphatidylinositol 3-kinase (PI3K) as provided by Foulstone ...
Collectively, these observations lead to the conclusion that there is, indeed, a biological basis for mental health conditions, as well as for the sex bias which characterises them, indicating that diagnostic, treatment and preventative strategies should be differentially targeted in men and women. ...