Elastin-like peptides (ELPs) are derivatives of tropoelastin with a unique property that allows them to stay soluble below a certain critical temperature but reversibly form aggregates above that temperature. Since they are derived from tropoelastin, ELPs are biocompatible, n...
Elastin-like polypeptides (ELPs) are biopolymers composed of short repeating peptide motifs inspired by the native elastin hydrophobic domains, mostly the pentapeptide VPGXG, where X is a guest residue, which can be any amino acid except proline. The ability to control the hydrophobicity of ELPs...
elastin-like peptides (ELP) spider structure complex including multi-leg moieties comprising ELP fusion proteins capable of forming covalent disulfide bonds; employed in peptide production and purification and/or to enhance protelytic resistance of a protein or peptide moiety in a fusion constructUS ...
Recent experimental work has shown that a delivery construct consisting of an ELP-therapeutic peptide (e.g., the c-Myc-inhibitory peptide, or the p21(WAF1/CIP1)-derived peptide), as well as ELP-small molecule drugs (e.g., doxorubicin, paclitaxel), can be thermally targeted to accumulate ...
Truncated elastin-like peptides (ELPs) are peptides consisting of repetitive sequences, derived from the elastic protein tropoelastin, that show the thermosensitive formation of coacervates. In this study, to obtain shortened ELP analogues, we synthesized several (Phe-Pro-Gly-Val-Gly)n (FPGVG)n...
Elastin-like polypeptides (ELPs) are thermally responsive biopolymers derived from natural elastin. These peptides have a low critical solution temperature phase behavior and can be used to prepare stimuli-responsive biomaterials. Through genetic enginee
Peptide and protein PEGylation: a review of problems and solutions. Biomaterials, 2001, 22: 405–417 Article Google Scholar Bailon P, Palleroni A, Schaffer CA, et al. Rational design of a potent, long-lasting form of interferon: a 40 kDa branched polyethylene glycol-conjugated interferon ...
ShortElastin-likePeptidesExhibittheSame Temperature-inducedStructuralTransitionsasElastin Polymers:ImplicationsforProteinEngineering HeraldReiersen 1 ,AnthonyR.Clarke 2 andAnthonyR.Rees 1 * 1 DepartmentofBiology& Biochemistry,Universityof Bath,ClavertonDown,Bath BA27AY,UK 2 DepartmentofBiochemistry Universityof...
The present study has been undertaken with the aim to characterize a chemically synthesized elastin-like peptide (VGGVG)3. Structural and biological features were compared with those of peptides as poly(VGGVG) and VGGVG that, having the same amino acid sequence, but different length and supramol...
1), as they are completely disordered polypeptides composed only of repeats of short peptide motifs. Hence, we suggest they can be thought of as representing a minimal, prototypical IDP. Herein, we analyze the relationship of ELPs to IDPs and seek to explore how cross-talk between the ...