Elacridar is a potent P-glycoprotein (Pgp) and BCRP inhibitor, used for cancer treatment. ChemeGen 作为优秀的抑制剂、激动剂及新型生命科学试剂的供应商,致力于为广大科研、商业实验室的科学研究者提供高品质的产品与技术服务,不断促进生命科学领域的新技术发展。 公司简介 ChemeGen 作为*的抑制剂、激动剂及...
Elacridar产品描述:Elacridar (GF120918; GW0918) is a P-glycoprotein inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules. IC50 value: Target: P-glycoprotein In ...
Elacridar依克立达抑制剂 Elacridar 是一种具有口服活性的的 P-glycoprotein (Pgp) 和 乳腺癌抗性蛋白 (BCRP) 抑制剂。Elacridar 可用于检测外排转运体对活性分子脑内分布的影响以及癌症的研究。 MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务 生物活性 体外研究 Elacridar(0.001-1 μM...
产品描述Elacridar is a P-glycoprotein (P-gp) inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules. In vitro, GF120918A demonstrated high plasma protein binding...
MDCK2-MDR1 Function assay 60 mins Inhibition of human Pgp overexpressed in human MDCK2-MDR1 cells assessed as inhibition of R123 efflux after 60 mins, IC50=0.4μM 21419632 MDCK Function assay Inhibition of BCRP expressed in MDCK cells by pheophorbide A assay, IC50=0.43μM 19932960 MCF7 MX ...
6-tetradecyl-β-D-maltopyranoside, (C6-malt)Membrane vesicles BCRPPhosphate release measurementsReduced Pgp ATPase activity.K2 = 4.6 103µM(Xu et al., 2015) BL-9EX, Dodecylnonaglycol, Polyoxyethylene (9) lauryl ether, C12EO90.05% and 0.075%SulfasalazineRat intestinal membraneIn vitro DCM...
Elacridar (GF120918; GW0918) is a P-glycoprotein inhibitor and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules. A prototypical BCRP (ABCG2) inhibitor. 关联靶点(人) 关...
Elacridar hydrochloride (GF120918A) 是一种有效的 P-糖蛋白 (P-glycoprotein) 和 BCRP 的抑制剂。 Elacridar hydrochloride (GF120918A) is a potent P-glycoprotein (Pgp) and BCRP inhibitor. 关联靶点(人) 关联靶点(其它种属) 名称和识别符 化学和物理性质 ...
Aim of this study was to label the potent dual P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) inhibitor elacridar (1) with 18F to provide a positron emission tomography (PET) radiotracer to visualize Pgp and BCRP. A series of new 1- and 2-halogen- and nitro-substituted...
英文别名Elacridar hydrochloride;GF 120918A;GF120918A;GF-120918A; SMILES 化学名称 分子式C34H33N3O5.ClH分子量600.11 纯度98%配送惯例下常温包邮 产品描述Elacridar hydrochloride is a P-glycoprotein inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) ...