9: EGFR-AS1: A potential biomarker for sensitivity to EGFR TKIs in NSCLC?Epithelial mesenchymal transition (EMT), the adoption by epithelial cells of a mesenchymal-like phenotype, is a process co-opted by carcinoma cells in order to initiate invasion and metastasis. In addition, it is becoming...
内容提示: 分类号』II II II I II III I IIIIIY3381 926论文编号密 级海军军医大学硕士学位论文长链非编码RNA EGFR.ASl在肾癌发展和转移中的作用及机制研究The Role of Longnon--coding RNAEGFR--ASl inthe Development and Metastasis of Renal Cancer研究生姓名: 王安邦 学号:20151135指导教师: 王林辉教授...
Ultimately, overexpressed ACTN4 could reserve the suppressive role of EGFR-AS1 silencing in CC cell growth. Last but not least, EGFR-AS1 facilitated CC cell growth via ACTN4-mediated WNT pathway. Conclusions: H3K27ac-activated EGFR-AS1 sponged miR-2355-5p and promoted CC cell growth ...
Recently, extensive studies unveiled that lncRNAs exert critical function in the development and progression of cervical cancer (CC). EGFR-AS1 is a novel lncRNA which has not been well-explored in CC. Our study aimed to research the function and molecula
FAM83A-AS1 Wnt/β-catenin EGFR Tumor progression 1. Introduction The FAM83 family consists of eight members characterized by a highly conserved DUF1669 domain located in the N-terminus whose function is unknown [1]. FAM83 proteins mediate interactions with casein kinase 1 (CK1) subtypes through...
EGFR-AS1(EGFR antisense RNA 1) 基因基本信息 基因基本信息 基因简称(symbol) EGFR-AS1[HGNC][GeneCards][NCBI] 基因种类(locus group) non-coding RNA 同源简称(alias symbol) 基因家族代码(gene_family_id) [HGNC][GenScript] omim代码 entrez码
In addition, high level expression of PTBP1 and its binding site in EGFR and EGFR-AS1 enhances the expression of EGFR-A isoform (r=0.7404, p<0.0001) suggesting that EGFR-AS1 expression modulates the EGFR-A and D isoforms through alternative splicing. In addition, this polymorphism creates a ...
The lncRNA epidermal growth factor receptor antisense RNA 1 (EGFR-AS1) was recently discovered to be aberrantly expressed in many types of diseases, particularly in cancers. A high level of EGFR-AS1 was demonstrated to correlate with multiple patient clinical characteristics. More importantly, EGFR-...
长链非编码RNAs (LncRNAs)是一类长度大于200 nt的非编码RNAs (ncRNAs),在正常生命活动及疾病进展中发挥着重要作用.文章从LncRNA EGFR-AS1的结构,在细胞中的定位,对EGFR调控,及对靶向治疗的影响等方面,综述了EGFR-AS1与癌症发生发展的关系.最后指出EGFR-AS1可能作为新的靶点,为肿瘤诊断和治疗提供参考.毛照阳沈一鸣...
The Cancer Genome Atlas (TCGA) demonstrates that EGFRAS1 is highly expressed in NSCLC. Downregulation of EGFRAS1 in A549 and PC9 NSCLC cells demonstrates inhibition of NSCLC proliferation, invasion and metastasis. The present study demonstrated that lncRNA EGFRAS1 was essential for the development of...