长链非编码RNAs (LncRNAs)是一类长度大于200 nt的非编码RNAs (ncRNAs),在正常生命活动及疾病进展中发挥着重要作用.文章从LncRNA EGFR-AS1的结构,在细胞中的定位,对EGFR调控,及对靶向治疗的影响等方面,综述了EGFR-AS1与癌症发生发展的关系.最后指出EGFR-AS1可能作为新的靶点,为肿瘤诊断和治疗提供参考.毛照阳沈一鸣...
临床样本验证发现EGFR-AS1在肾癌组织中显著上调表达,并且EGFR-AS1的高表达与TNM分期,T分期和淋巴结转移有关。(2)细胞功能学实验表明,EGFR-AS1能促进肾癌细胞的增殖和转移,体外实验研究表明,下调EGFR-AS1后能降低肾癌细胞的增殖和转移能力。(3)在肾癌组织标本中,发现EGFR的表达和EGFR-AS1表达量呈显著正相关。EGFR-...
FAM83A-AS1 Wnt/β-catenin EGFR Tumor progression 1. Introduction The FAM83 family consists of eight members characterized by a highly conserved DUF1669 domain located in the N-terminus whose function is unknown [1]. FAM83 proteins mediate interactions with casein kinase 1 (CK1) subtypes through...
EGFR-AS1(EGFR antisense RNA 1) 基因基本信息 基因基本信息 基因简称(symbol) EGFR-AS1[HGNC][GeneCards][NCBI] 基因种类(locus group) non-coding RNA 同源简称(alias symbol) 基因家族代码(gene_family_id) [HGNC][GenScript] omim代码 entrez码
Ultimately, overexpressed ACTN4 could reserve the suppressive role of EGFR-AS1 silencing in CC cell growth. Last but not least, EGFR-AS1 facilitated CC cell growth via ACTN4-mediated WNT pathway. H3K27ac-activated EGFR-AS1 sponged miR-2355-5p and promoted CC cell growth through ACTN4-...
Using publicly available transcriptome sequencing data from renal cancer ( = 703) and integrating bioinformatics analyses, we screened and identified a valuable lncRNA, EGFR-AS1. In our validation cohort ( = 204), EGFR-AS1 was significantly upregulated in RCC tissues ( 0.001). ...
9: EGFR-AS1: A potential biomarker for sensitivity to EGFR TKIs in NSCLC?Epithelial mesenchymal transition (EMT), the adoption by epithelial cells of a mesenchymal-like phenotype, is a process co-opted by carcinoma cells in order to initiate invasion and metastasis. In addition, it is becoming...
More importantly, EGFR-AS1 was found to be involved in the mediation of various cellular activities, including cell proliferation, invasion, migration, chemosensitivity, and stemness. Therefore, EGFRAS1 is a promising marker for cancer management. In this review, we introduce ...
在表观遗传,转录以及转录后等多个水平调控基因表达进而影响细胞增殖,分化与凋亡.越来越多的证据表明,lncRNA在各种人类疾病,尤其是肿瘤发生发展中起到至关重要的作用.其中,lncRNA EGFR-AS1 (EGFR antisense RNA 1)的异常表达与多种肿瘤的发生发展密切相关.全文对EGFR-AS1在不同肿瘤发生发展中的功能与潜在分子机制做...
EGFR-AS1esophageal squamous cell carcinomamiR-145ROCK1survivalBackground: EGFR-AS1 has been characterized as an oncogenic lncRNA in many types of cancers, while its roles in esophageal squamous cell carcinoma (ESCC) are unknown.Feng, ZhiLi, XuQiu, MinglianLuo, RonggangLin, JianboLiu, Bo...