In addition, high level expression of PTBP1 and its binding site in EGFR and EGFR-AS1 enhances the expression of EGFR-A isoform (r=0.7404, p<0.0001) suggesting that EGFR-AS1 expression modulates the EGFR-A and D isoforms through alternative splicing. In addition, this polymorphism creates a ...
后续实验更证明 EGFR-AS1 是影响标靶药物疗效的关键,因为若以 RNAi 技术将未发生 G/A 突变的癌细胞内 EGFR-AS1 表现压低,此时标靶药物即能较有效地抑制癌细胞生长;反之在发生 G/A 突变的癌细胞大量表现 EGFR-AS1 时,标靶药物抑制其生长的能力会降低。 本次研究发现,除了先前已知的 EGFR 突变可预测病患是否能受...
最后,抗EGFR和抗VEGF联合治疗比单一抗VEGF治疗显示出更好的肿瘤抑制效果,有利于优化鼻咽癌的临床治疗。 优点:肿瘤发病过程中EGFR过度激活的机制主要与EGFR或其配体的过表达有关4例如,长非编码RNA,EGFR-AS1被证明直接结合EGFR mRNA,通过上调...
Recently, extensive studies unveiled that lncRNAs exert critical function in the development and progression of cervical cancer (CC). EGFR-AS1 is a novel lncRNA which has not been well-explored in CC. Our study aimed to research the function and molecula
Li and Wang Biology Direct (2022) 17:3 https://doi.org/10.1186/s13062-021-00315-5 RESEARCH Open Access H3K27ac‑activated EGFR‑AS1 promotes cell growth in cervical cancer through ACTN4‑mediated WNT pathway Jingyan Li1 and Hongbing Wang2* Abstract Background:...
同时发现该SNP位点还位于EGFR基因座的反义非编码转录本lncRNA EGFR-AS1中,利用单核苷酸编辑技术替换EGFR-AS1的转录本中的核苷酸可以逆转G/G基因型细胞系对EGFR TKI的耐药性;进一步研究发现降低EGFR-AS1的表达水平可以导致EGFR亚型A和D的差异性剪切,升...
Interestingly, in DiFi62 drug-resistant variant cells, a novel loss of copy number of 48.584 kb in length in the EGFR and EGFR-AS1 genes corresponding to the regions encoding for the intracellular domain of the EGFR protein was also detected, which was not present in DiFi parental or DiFiG...
基因EGFR-AS1 长基因名EGFR反义RNA 1 位点7p11.2 发现年份2012-11-06 Entrez基因记录100507500 公开标识26271667 28920960 参考序列标识NR_ 分类长非编码RNA(已发布)[哈瓦那BLAST/BLAT-otthumg0000156126 MeSH数据 名称印迹,Western 树编号05.196.401.143E05.301.300.096E05.478.566.320.200E05.601.262E05.601.470.320.200...
[18]Qin Y,Sun W,Zhang H,et al.LncRNA GAS8-AS1 inhibits cell proliferation through ATG5-mediated autophagy in papillary thyroid cancer.Endocrine,2018,59:555-564. [19]Ndoye A,Budinakolomets A,Kugel CH,et al.ATG5 mediates a positive feedback loop between Wnt signaling and autophagy in melan...