[49]. However, for the same cohort, PFS was negatively affected by the presence of T790M, even under treatment with third-line TKI osimertinib. This finding could be explained under the theory of T790M as one possible intrinsic resistance mechanism. However, T790M can also favor other ...
As described above, our results revealed different tumor cell clusters with DEGs enriched in distinct pathways, implying progressional heterogeneity among them. We then asked if the single-cell transcriptome could gain temporal information of differentiation states during LUAD progression. We pooled all ...