What does the test result mean? If an individual’s lung cancer has an sensitizingEGFRmutation, then an EGFR-targeted tyrosine kinase inhibitor (TKI) may be effective in treating the tumor. If no sensitizing mutation is detected by theEGFRtest, then the tumor is less likely to respond to TK...
Results show mean ± SEM. ∗, p < 0.05, Mann-Whitney test. (D) PCA of CAFs and malignant cells flow-sorted from vehicle- and ERBBi-treated PDAC tumors, as described in (A). (E) RNA-seq analysis of CAFs flow-sorted from ERBBi- (n = 4) or vehicle- (n = 4) treated PDAC ...
The concordance rate of intratumoral EGFR copy number alteration (low gene copy number vs high gene copy number) was 86% (89/103) with a mean kappa value of 0.793 (P<0.001) (Table 5). Specifically, the three cases with EGFR gene amplification showed homogenous EGFR gene amplification and ...
The data were expressed as the mean ± standard deviation of three independent experiments. The p-value < 0.05 was considered statistically significant, and “ns” indicated no statistical difference. Results Shikonin exhibited cytotoxic effects against H1975 cells H1975 cells, harboring the ...
Assumptions of normality were tested using the Shapiro–Wilk test, and Bonferroni corrections for multiple comparisons were applied. A p value <0.05 was considered statistically significant. Results Single-cell RNA-seq analysis of pancreatic islets during pregnancy and postpartum To investigate cellular ...
Data are mean ± s.e.m. and were analyzed with an unpaired two-tailed t-test (A, B, C, G). Full size image Our previous data showed that AICAR-induced ROS increased in vitro. ROS is eliminated by endogenous and exogenous antioxidant metabolites such as glutathione and ascorbic acid...
Scale bar 20 µm, image analysis of mean pixel intensity per nucleus. Western analysis (C) of total and phospho ERK (Thr202/Tyr204) relative to control siRNA (N = 5). Two-way ANOVA (C), one-sample t test (A, D); significance denoted by *P < 0.05, **P < ...
Data were plotted as mean ± SEM from at least 3 independent experiments as indicated in the figure legends. Statistical analysis was performed with unpaired two-tailed Student’s t test using GraphPad Prism (version 9). P < 0.05 was considered significant. Reporting summary Further info...
The data displayed in this study were mean ± SD. The two-tailed Student’s t test was used for difference analysis between any two groups, one-way analysis of variance followed by Bonferroni post hoc test was applied for difference analysis among multiple groups. The spearman correlation ...
Results: EGFR mutations were detected in 196 of 382 NSCLCs (51.3%) and were more frequent in women than in men (65.7% versus 34.3%, p < 0.001) and in nonsmokers than in smokers (63.4% versus 32.0%, p < 0.001). Regarding histologic subtypes of adenocarcinoma, mixed acinar and BAC pat...