An individual patient-level meta-analysis of non–small-cell lung cancer leptomeningeal metastases treated with epidermal growth factor receptor inhibitors. e21118#Background:Leptomeningeal metastasis (LM) is a debilitating condition associated with advanced non-small cell lung cancer (NSCLC). When driver...
P-969 The level of EGFR phosphorylation in NSCLC core biopsies fromin situ tumor prior to vessel ligation may be more accurate than tissue obtained immediately after lobectomydoi:10.1016/S0169-5002(05)81462-XElsevier Ireland LtdLung Cancer
[3]Zhang Y, Li S, Lyu Z, et al. The co-mutation of EGFR and tumor-related genes leads to a worse prognosis and a higher level of tumor mutational burden in Chinese non-small cell lung cancer patients[J]. Journal of Thoracic Disease, 2022, 14(1): 185-193. DOI: 10.21037/jtd-21...
A high level of epidermal growth factor receptor (EGFR) expression in non-small cell is a good predictor for increased survival with cetuximab added to first-line , according to a major study reported at the World Conference on Lung Cancer (4 July; Amsterdam, The Netherlands). The phase III...
EGFRvIII expression is associated with the activation of downstream PI3K/AKT/mTOR pathway and increases proliferation and cell cycle progression mediated by a decrease in the level of p27KIP1. EGFRvIII also has been shown to activate the NF-κB pathway and regulate expression of IL-835. Further...
Increasing evidence points to the presence of low-level de novo T790M mutations in patients with non-small cell lung carcinoma (NSCLC) harboring activating EGFR mutations. We utilized digital PCR (dPCR), a highly sensitive gene mutation detection method, to detect pre-treatment T790M mutations in...
This is a similar argument to that made for the ability of EGFR variant III (vIII) to promote transformation despite being reported to have only a low level of constitutive activity40,41. In this scenario, one might predict that altered sensitivity to osimertinib is more modest than that ...
疗效 毒性 选择 EGFR状态作为结直肠癌的预后因素 82%的结直肠癌EGFR有不同程度的表达 与RFS相关性(%)60(n=5)75(n=4)0(n=1)与OS相关性(%)63(n=11)71(n=7)69(n=13)Frequency(%)ofstudiesshowinganassociationbetweenincreasedEGFRlevelanddecreasedsurvival 肿瘤类型 EGFR作为强烈预后指标 膀胱癌宫颈癌...
The preceding species, which constituted a considerable 99% of the population, gave way on day 22 to a yet-undetermined microalga of the Chlorophyta phylum, reaching a level exceeding 61%. After inoculation into the reactor, the granules hosted a proliferating bacterial community, its composition ...
This indicates that the expression level of EGFR in HT29 cells is lower than that in A431 cells, while HeLa cells expressed the lowest level of EGFR among the three cell lines. In order to elucidate the targeting property of CPP with the sequence NRPDSAQFWLHH towards EGFR, the FITC-...