Photodynamic therapy (PDT) induces cell death through local light activation of a photosensitizer (PS) and has been used to treat head and neck cancers. Yet, common PS lack tumor specificity, which leads to collateral damage to normal tissues. Targeted delivery of PS via antibodies has pre-clin...
EGFR-targeted photosensitizer for enhanced photodynamic therapy and imaging therapeutic effect by monitoring GSH declineKunshan HuangYanan NiuGankun YuanMeiqi YanJinping XueJuanjuan Chen
Here we present a novel approach to bladder cancer therapy using a combination of cell surface targets to enhance the anti-tumor effects of photoimmunotherapy. Taking advantage of the high molecular heterogeneity in bladder cancer, we targeted cancer that expresses both cell-surface EGFR and HER2. ...
The broad long-term research objective is to develop an effective nanomedicine platform for targeted delivery of the photosensitizer drug Pc 4 to sites of head and neck cancer to enhance the clinical repertoire of Pc 4-induced photodynamic therapy (PDT) in these malignancies. The specific aims ...
While targeted therapy has played a crucial role, the emergence of EGFR resistance and adverse reactions has made it imperative to explore new medications. Natural products derived from plants became an important source of anti-tumor drugs. In this study, nine known compounds, including seven ...
EGFR-mediated intracellular delivery of Pc 4 nanoformulation for targeted photodynamic therapy of cancer: in vitro studie Pc 4 was delivered in block-copolymer micelles surface-modified with GE11 peptides targeting EGFR-overexpressing cancer cells.Alyssa M. Master... AM Master,Y Qi,NL Oleinick,.....
To maximize the benefits of TLR activation in cancer therapy, it is essential to selectively target TLRs in the appropriate immune cells while avoiding their activation in tumor cells22. This targeted approach can enhance anti-tumor immunity and improve the therapeutic outcome. Most TLR agonists ...
JAK2/STAT3 targeted therapy suppresses tumor invasion via disruption of the EGFRvIII/JAK2/STAT3 axis and associated focal adhesion in EGFRvIII-expressing glioblastoma. Neuro Oncol 2014; 16: 1229–1243. Article CAS PubMed PubMed Central Google Scholar Lindemann C, Hackmann O, Delic S, Schmidt N,...
B. Dual-surface modified virus capsids for targeted delivery of photodynamic agents to cancer cells. ACS Nano 4, 6014–6020. https://doi.org/10.1021/nn1014769 (2010). Article CAS PubMed Google Scholar Wynne, S. A., Crowther, R. A. & Leslie, A. G. The crystal structure of the ...
EGFR activation status predicts, among other things, the aggressiveness of EGFR-positive neoplasms and/or the potential efficacy of EGFR-targeted therapies that depend at least in part upon EGFR activation status. The disclosed methods involve the use of antigen-binding molecules (also referred to ...